The relationship between Graves’ ophthalmopathy and dry eye syndrome

Jessica H. Selter, Anisa I. Gire, Shameema Sikder

Research output: Contribution to journalReview article

Abstract

Background: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.

Methods: A review of the literature was conducted using the query terms “Graves’ Ophthal-mopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.

Conclusion: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalClinical Ophthalmology
Volume9
DOIs
StatePublished - Dec 31 2014

Keywords

  • Dry eye
  • Graves’ ophthalmopathy
  • Ocular inflammation
  • Thyroid eye disease

ASJC Scopus subject areas

  • Ophthalmology

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