The relationship between dietary protein intake and blood pressure: Results from the PREMIER study

Youfa Wang, W. S. Yancy, D. Yu, C. Champagne, Lawrence Appel, P. H. Lin

Research output: Contribution to journalArticle

Abstract

Observational and clinical studies suggest that high protein intake, particularly protein from plant sources, might reduce blood pressure (BP). To examine the association of dietary protein with BP, we analysed data from PREMIER, an 18-month clinical trial (n=810) that examined the effects of two multi-component lifestyle modifications on BP. We examined the association of protein intake with BP, and in particular the independent relationship of plant and animal protein with BP. Multivariable linear regression analyses were performed with both cross-sectional and longitudinal data. Dietary plant protein was inversely associated with both systolic and diastolic BP in cross-sectional analyses at the 6-month follow-up (P=0.0045 and 0.0096, respectively). Fruit and vegetable intake was also inversely associated with both systolic and diastolic BP cross-sectionally at 6 months (P=0.0003 and 0.0157, respectively). In longitudinal analyses, a high intake of plant protein at 6 months was marginally associated with a reduction of both systolic and diastolic BP from baseline to 6 months only (P=0.0797 and 0.0866, respectively), independent of change in body weight and waist circumference. Furthermore, increased intake of plant protein, and fruits and vegetables was significantly associated with a lower risk of hypertension at 6 but not at 18 months. Results of this study indicate that plant protein had a beneficial effect on BP and was associated with a lower risk of hypertension at 6 months. Our data, in conjunction with other research, suggest that an increased intake of plant protein may be useful as a means to prevent and treat hypertension.

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalJournal of Human Hypertension
Volume22
Issue number11
DOIs
StatePublished - 2008

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Dietary Proteins
Blood Pressure
Plant Proteins
Hypertension
Vegetables
Fruit
Vegetable Proteins
Body Weight Changes
Waist Circumference
Observational Studies
Life Style
Linear Models
Proteins
Cross-Sectional Studies
Regression Analysis
Clinical Trials

ASJC Scopus subject areas

  • Internal Medicine

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The relationship between dietary protein intake and blood pressure : Results from the PREMIER study. / Wang, Youfa; Yancy, W. S.; Yu, D.; Champagne, C.; Appel, Lawrence; Lin, P. H.

In: Journal of Human Hypertension, Vol. 22, No. 11, 2008, p. 745-754.

Research output: Contribution to journalArticle

Wang, Youfa ; Yancy, W. S. ; Yu, D. ; Champagne, C. ; Appel, Lawrence ; Lin, P. H. / The relationship between dietary protein intake and blood pressure : Results from the PREMIER study. In: Journal of Human Hypertension. 2008 ; Vol. 22, No. 11. pp. 745-754.
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