TY - JOUR
T1 - The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6-8 years - The questionnaire study results
AU - Raciborski, Filip
AU - Tomaszewska, Aneta
AU - Komorowski, Jarosław
AU - Samel-Kowalik, Piotr
AU - Białoszewski, Artur Z.
AU - Artur, Walkiewicz
AU - Lusawa, Adam
AU - Szymański, Jakub
AU - Opoczyńska, Dagmara
AU - Druzba, Michał
AU - Borowicz, Jacek
AU - Lipiec, Agnieszka
AU - Kapalczynski, Wojciech J.
AU - Samoliński, Bolesław
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012/9
Y1 - 2012/9
N2 - Introduction: Studies based on the ISAAC questionnaire suggest a correlation between the use of antibiotics and the prevalence of asthma and allergy in children aged 6-7 years. The number of courses of antibiotic therapy is an important factor. Objectives: To investigate the relationship between the use of antibiotics during the first years of life and the prevalence of allergy and asthma among children (aged 6-8 years) in the urban population of Poland. Materials and Methods: A survey-based study with a self-completed questionnaire. The respondents were parents of children aged 6-8 years living in Warszawa, Poland. 1461 completed questionnaires were collected. Results: Asthma was declared in 4.3% of the children. Wheezing and/or sibilant rhonchi within 12 months before the study was observed in 13.5% of the cases. Asthma medication was taken by 21.8% of the children. Allergic rhinitis was declared in 18.7% of the children. Problems with sneezing, rhinorrhea, and nasal congestion not associated with cold or fever were observed in 40.7% of the children. The analysis of the odds ratios between the use of antibiotics and the symptoms of allergic diseases revealed a clear correlation. The highest odds ratio was observed between the completion of over three courses of antibiotic therapy prior to the age of 12 months and the declaration of one of the following: asthma (OR = 5.59, 95% CI: 2.6-12.01), wheezing and/or sibilant rhonchi (OR = 4.68, 95% CI: 3.01-7.27) and taking medicines for breathlessness (OR = 5.12, 95% CI: 3.42-7.68). Conclusions: There is a direct relationship between antibiotic use in the first 3 years of life and asthma and allergy symptoms in children aged 6-8 years old.
AB - Introduction: Studies based on the ISAAC questionnaire suggest a correlation between the use of antibiotics and the prevalence of asthma and allergy in children aged 6-7 years. The number of courses of antibiotic therapy is an important factor. Objectives: To investigate the relationship between the use of antibiotics during the first years of life and the prevalence of allergy and asthma among children (aged 6-8 years) in the urban population of Poland. Materials and Methods: A survey-based study with a self-completed questionnaire. The respondents were parents of children aged 6-8 years living in Warszawa, Poland. 1461 completed questionnaires were collected. Results: Asthma was declared in 4.3% of the children. Wheezing and/or sibilant rhonchi within 12 months before the study was observed in 13.5% of the cases. Asthma medication was taken by 21.8% of the children. Allergic rhinitis was declared in 18.7% of the children. Problems with sneezing, rhinorrhea, and nasal congestion not associated with cold or fever were observed in 40.7% of the children. The analysis of the odds ratios between the use of antibiotics and the symptoms of allergic diseases revealed a clear correlation. The highest odds ratio was observed between the completion of over three courses of antibiotic therapy prior to the age of 12 months and the declaration of one of the following: asthma (OR = 5.59, 95% CI: 2.6-12.01), wheezing and/or sibilant rhonchi (OR = 4.68, 95% CI: 3.01-7.27) and taking medicines for breathlessness (OR = 5.12, 95% CI: 3.42-7.68). Conclusions: There is a direct relationship between antibiotic use in the first 3 years of life and asthma and allergy symptoms in children aged 6-8 years old.
KW - Allergy
KW - Antibiotics
KW - Asthma
KW - Epidemiology
KW - Prevalence
KW - Risk factors
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U2 - 10.2478/S13382-012-0056-0
DO - 10.2478/S13382-012-0056-0
M3 - Article
C2 - 23212289
AN - SCOPUS:84874388836
VL - 25
SP - 470
EP - 480
JO - International Journal of Occupational Medicine and Environmental Health
JF - International Journal of Occupational Medicine and Environmental Health
SN - 1232-1087
IS - 4
ER -