The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women

Howard D. Strickler, Jeffrey Martinson, Seema Desai, Xianhong Xie, Robert D. Burk, Kathryn Anastos, L. Stewart Massad, Howard Minkoff, Xiaonan Xue, Gypsyamber D'Souza, Alexandra M. Levine, Christine Colie, D. Heather Watts, Joel M. Palefsky, Alan Landay

Research output: Contribution to journalArticle

Abstract

Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalViral Immunology
Volume27
Issue number1
DOIs
StatePublished - Feb 1 2014

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ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

Strickler, H. D., Martinson, J., Desai, S., Xie, X., Burk, R. D., Anastos, K., Massad, L. S., Minkoff, H., Xue, X., D'Souza, G., Levine, A. M., Colie, C., Watts, D. H., Palefsky, J. M., & Landay, A. (2014). The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women. Viral Immunology, 27(1), 20-25. https://doi.org/10.1089/vim.2013.0097