The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by Brequinar Sodium

E. de Kant, H. M. Pinedo, E. Laurensse, G. J. Peters

Research output: Contribution to journalArticlepeer-review

Abstract

The growth inhibitory effects of Breqinar Sodium (DUP-785; NSC 368390) in 7 different cell lines were related to growth rates and to the inhibition of dihydroorotic acid dehydrogenase (DHO-DH) activity. IC50 values were between 0.2 and 5.8 μM; the fastest growing cell line was least sensitive. Despite a large variation in sensitivity, basal activity of DHO-DH showed little variation (only 2-fold) between the different cell lines. Residual activity of DHO-DH in the presence of Brequinar Sodium varied 30-fold. Drug sensitivity correlated with this residual DHO-DH activity; DHO-DH activity was only slightly inhibited by Breqinar Sodium in the most resistant lines, and almost completely in the most sensitive.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalCancer Letters
Volume46
Issue number2
DOIs
StatePublished - Jul 15 1989
Externally publishedYes

Keywords

  • Breqinar Sodium (DUP-785)
  • dihydroorotic acid dehydrogenase
  • growth inhibition
  • pyrimidine de novo

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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