The regulation and function of inositol 1,4,5-trisphosphate 3-kinases

Robin F. Irvine, Samantha M. Lloyd-Burton, Jowie C H Yu, Andrew J. Letcher, Michael J. Schell

Research output: Contribution to journalArticle


It is 20 yr since the Ins(1,4,5)P3 3-kinase reaction was discovered, and this review summarizes and discusses some of the advances we have made in our understanding of the physiological significance of this reaction. The three major potential functions of Ins(1,4,5)P3 3-kinases are discussed in the context of their localization and regulation, the possible functions of their product, Ins(1,3,4,5)P4 and their potential contribution to the synthesis of higher inositol polyphosphates.

Original languageEnglish (US)
Pages (from-to)314-323
Number of pages10
JournalAdvances in Enzyme Regulation
Issue number1
StatePublished - 2006
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Irvine, R. F., Lloyd-Burton, S. M., Yu, J. C. H., Letcher, A. J., & Schell, M. J. (2006). The regulation and function of inositol 1,4,5-trisphosphate 3-kinases. Advances in Enzyme Regulation, 46(1), 314-323.