The redistribution of collagen in expanded pig skin

Kenneth R. Knight, John J. McCann, Craig Vander Kolk, Serena A. Coe, Bernard McC O'Brien

Research output: Contribution to journalArticle

Abstract

Silicone tissue expanders were inserted subcutaneously in the buttocks of nine young pigs and gradually inflated to maximum capacity over 5 weeks. On the control side the expanders were left uninflated. Island buttock flaps were then raised, the expanders removed and the flaps spread into the same sites for 10 days. The tissue was harvested. Area measurements and full thickness skin biopsies were taken 10 days after flap inset in order to study the changes in collagen composition and isotypes in the skin layers. Ten days after inset of the flap the expanded skin had a mean 47% increase in surface area, was 9% thinner (from surface to implant), mostly due to thinning of the subcutaneous zone, but was not significantly different in water content, relative to the control skin. The expanded skin had a significant 9.3% increase (P<0.01, t test) in collagen content of the dermis. The relative proportions of Types I and III were not significantly changed by skin expansion in either the dermal/epidermal or subcutaneous/capsular zones. It is speculated that tensile factors during expansion stimulate the biosynthetic activity and/or mitotic activity of fibroblasts in the dermis to produce this gain in collagen in the expanded compared with unexpanded tissue.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalBritish Journal of Plastic Surgery
Volume43
Issue number5
DOIs
StatePublished - Jan 1 1990

Fingerprint

Swine
Collagen
Skin
Buttocks
Dermis
Tissue Expansion Devices
Surgical Flaps
Silicones
Fibroblasts
Biopsy
Water

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Knight, K. R., McCann, J. J., Vander Kolk, C., Coe, S. A., & O'Brien, B. M. (1990). The redistribution of collagen in expanded pig skin. British Journal of Plastic Surgery, 43(5), 565-570. https://doi.org/10.1016/0007-1226(90)90121-F

The redistribution of collagen in expanded pig skin. / Knight, Kenneth R.; McCann, John J.; Vander Kolk, Craig; Coe, Serena A.; O'Brien, Bernard McC.

In: British Journal of Plastic Surgery, Vol. 43, No. 5, 01.01.1990, p. 565-570.

Research output: Contribution to journalArticle

Knight, KR, McCann, JJ, Vander Kolk, C, Coe, SA & O'Brien, BM 1990, 'The redistribution of collagen in expanded pig skin', British Journal of Plastic Surgery, vol. 43, no. 5, pp. 565-570. https://doi.org/10.1016/0007-1226(90)90121-F
Knight KR, McCann JJ, Vander Kolk C, Coe SA, O'Brien BM. The redistribution of collagen in expanded pig skin. British Journal of Plastic Surgery. 1990 Jan 1;43(5):565-570. https://doi.org/10.1016/0007-1226(90)90121-F
Knight, Kenneth R. ; McCann, John J. ; Vander Kolk, Craig ; Coe, Serena A. ; O'Brien, Bernard McC. / The redistribution of collagen in expanded pig skin. In: British Journal of Plastic Surgery. 1990 ; Vol. 43, No. 5. pp. 565-570.
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