The reaction of myelin phospholipids with phospholipase C and D

M. Guarnieri; H. Syed; W. Weintraub; G. M. McKhann

doi:10.1016/0003-9861(75)90501-9

The reaction of myelin phospholipids with phospholipase C and D

M. Guarnieri, H. Syed, W. Weintraub, G. M. McKhann

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Phospholipase C and D hydrolyze the membrane-bound phospholipids of isolated, untreated myelin. When the membrane is treated with detergents or solvents which disrupt the membrane structure, the activity of the enzymes against the membrane-bound lipids increases. Myelin in the central nervous system is derived from the cell membrane of the oligodendroglial cell. Because the phospholipids in erythrocyte cell membranes are strikingly resistent to phospholipase C and D hydrolysis the question is raised of whether myelin in situ, as opposed to isolated myelin, is susceptible to phospholipase hydrolysis.

Original language	English (US)
Pages (from-to)	581-587
Number of pages	7
Journal	Archives of Biochemistry and Biophysics
Volume	167
Issue number	2
DOIs	https://doi.org/10.1016/0003-9861(75)90501-9
State	Published - Apr 1975

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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title = "The reaction of myelin phospholipids with phospholipase C and D",

abstract = "Phospholipase C and D hydrolyze the membrane-bound phospholipids of isolated, untreated myelin. When the membrane is treated with detergents or solvents which disrupt the membrane structure, the activity of the enzymes against the membrane-bound lipids increases. Myelin in the central nervous system is derived from the cell membrane of the oligodendroglial cell. Because the phospholipids in erythrocyte cell membranes are strikingly resistent to phospholipase C and D hydrolysis the question is raised of whether myelin in situ, as opposed to isolated myelin, is susceptible to phospholipase hydrolysis.",

author = "M. Guarnieri and H. Syed and W. Weintraub and McKhann, {G. M.}",

note = "Funding Information: {\textquoteleft}This research was supported by funds from the National Multiple Sclerosis Society, and USPHS Grants NS 10920 and NS 10465.",

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doi = "10.1016/0003-9861(75)90501-9",

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T1 - The reaction of myelin phospholipids with phospholipase C and D

AU - Guarnieri, M.

AU - Syed, H.

AU - Weintraub, W.

AU - McKhann, G. M.

N1 - Funding Information: ‘This research was supported by funds from the National Multiple Sclerosis Society, and USPHS Grants NS 10920 and NS 10465.

PY - 1975/4

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N2 - Phospholipase C and D hydrolyze the membrane-bound phospholipids of isolated, untreated myelin. When the membrane is treated with detergents or solvents which disrupt the membrane structure, the activity of the enzymes against the membrane-bound lipids increases. Myelin in the central nervous system is derived from the cell membrane of the oligodendroglial cell. Because the phospholipids in erythrocyte cell membranes are strikingly resistent to phospholipase C and D hydrolysis the question is raised of whether myelin in situ, as opposed to isolated myelin, is susceptible to phospholipase hydrolysis.

AB - Phospholipase C and D hydrolyze the membrane-bound phospholipids of isolated, untreated myelin. When the membrane is treated with detergents or solvents which disrupt the membrane structure, the activity of the enzymes against the membrane-bound lipids increases. Myelin in the central nervous system is derived from the cell membrane of the oligodendroglial cell. Because the phospholipids in erythrocyte cell membranes are strikingly resistent to phospholipase C and D hydrolysis the question is raised of whether myelin in situ, as opposed to isolated myelin, is susceptible to phospholipase hydrolysis.

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The reaction of myelin phospholipids with phospholipase C and D

Abstract

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