TY - JOUR
T1 - The re-emerging arboviral threat
T2 - Hidden enemies: The emergence of obscure arboviral diseases, and the potential use of Wolbachia in their control
AU - Dutra, Heverton Leandro Carneiro
AU - Caragata, Eric Pearce
AU - Moreira, Luciano Andrade
N1 - Publisher Copyright:
© 2016 WILEY Periodicals, Inc.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Mayaro, Oropouche, and O'Nyong-Nyong share many traits with more prominent arboviruses, like dengue and yellow fever, chikungunya, and Zika. These include severe clinical symptoms, multiple animal hosts, and widespread vector species living in close proximity to human habitats, all of which constitute significant risk factors for more frequent outbreaks in the future, greatly increasing the potential of these hidden enemies to follow Zika and become the next wave of global arboviral threats. Critically, the current dearth of knowledge on these arboviruses might impede the success of future control efforts, including the potential application of Wolbachia pipientis. This bacterium inherently possesses broad anti-pathogen properties and a means of genetic drive that allows it to eliminate or replace target vector populations. We conclude that control of obscure arboviruses with Wolbachia might be possible, but successful implementation will be critically dependent on the ability to transinfect key vector species.
AB - Mayaro, Oropouche, and O'Nyong-Nyong share many traits with more prominent arboviruses, like dengue and yellow fever, chikungunya, and Zika. These include severe clinical symptoms, multiple animal hosts, and widespread vector species living in close proximity to human habitats, all of which constitute significant risk factors for more frequent outbreaks in the future, greatly increasing the potential of these hidden enemies to follow Zika and become the next wave of global arboviral threats. Critically, the current dearth of knowledge on these arboviruses might impede the success of future control efforts, including the potential application of Wolbachia pipientis. This bacterium inherently possesses broad anti-pathogen properties and a means of genetic drive that allows it to eliminate or replace target vector populations. We conclude that control of obscure arboviruses with Wolbachia might be possible, but successful implementation will be critically dependent on the ability to transinfect key vector species.
KW - Mayaro
KW - O'Nyong-Nyong
KW - Oropouche
KW - Wolbachia
KW - Zika
KW - chikungunya
KW - dengue
UR - http://www.scopus.com/inward/record.url?scp=85007358336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007358336&partnerID=8YFLogxK
U2 - 10.1002/bies.201600175
DO - 10.1002/bies.201600175
M3 - Article
C2 - 28026036
AN - SCOPUS:85007358336
SN - 0265-9247
VL - 39
JO - BioEssays
JF - BioEssays
IS - 2
M1 - 1600175
ER -