The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): A prospective cohort study of childhood nephrotic syndrome

Neesha Hussain, J. Anastasia Zello, Jovanka Vasilevska-Ristovska, Tonny M. Banh, Viral P. Patel, Pranali Patel, Christopher D. Battiston, Diane Hebert, Christoph P B Licht, Tino D. Piscione, Rulan S. Parekh

Research output: Contribution to journalArticle

Abstract

Background: Nephrotic syndrome is one of the most commonly diagnosed kidney diseases in childhood and its progressive forms can lead to chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There have been few longitudinal studies among a multi-ethnic cohort to determine potential risk factors influencing disease susceptibility, treatment response, and progression of nephrotic syndrome. Temporal relationships cannot be studied through cross-sectional study design. Understanding the interaction between various factors is critical to developing new strategies for treating children with kidney disease. We present the rationale and the study design of a longitudinal cohort study of children with nephrotic syndrome, the Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT) study. The specific aims are to determine: 1) socio-demographic, environmental, and genetic factors that influence disease susceptibility; 2) rates of steroid treatment resistance and steroid treatment dependence, and identify factors that may modify treatment response; 3) clinical and genetic factors that influence disease susceptibility and progression to CKD and ESRD; and 4) the interaction between the course of illness and socio-demographic, environmental, and clinical risk factors. Methods/design. INSIGHT is a disease-based observational longitudinal cohort study of children with nephrotic syndrome. At baseline, participants complete questionnaires and provide biological specimen samples (blood, urine, and toenail clippings). Follow-up questionnaires and repeat biological specimen collections are performed annually for up to five years. Discussion. The proposed cohort will provide the structure to test various risk factors predicting or influencing disease susceptibility, treatment response, and progression to CKD among children with nephrotic syndrome. Trial registration. ClinicalTrials.gov Identifier NCT01605266.

Original languageEnglish (US)
Article number25
JournalBMC Nephrology
Volume14
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Nephrotic Syndrome
Cohort Studies
Prospective Studies
Disease Susceptibility
Health
Genes
Chronic Renal Insufficiency
Longitudinal Studies
Kidney Diseases
Therapeutics
Chronic Kidney Failure
Steroids
Demography
Specimen Handling
Nails
Disease Progression
Cross-Sectional Studies
Urine

Keywords

  • Children
  • Chronic kidney disease
  • Cohort
  • FSGS
  • Minimal change disease
  • Nephrotic syndrome
  • Study protocol

ASJC Scopus subject areas

  • Nephrology

Cite this

The rationale and design of Insight into Nephrotic Syndrome : Investigating Genes, Health and Therapeutics (INSIGHT): A prospective cohort study of childhood nephrotic syndrome. / Hussain, Neesha; Zello, J. Anastasia; Vasilevska-Ristovska, Jovanka; Banh, Tonny M.; Patel, Viral P.; Patel, Pranali; Battiston, Christopher D.; Hebert, Diane; Licht, Christoph P B; Piscione, Tino D.; Parekh, Rulan S.

In: BMC Nephrology, Vol. 14, No. 1, 25, 2013.

Research output: Contribution to journalArticle

Hussain, N, Zello, JA, Vasilevska-Ristovska, J, Banh, TM, Patel, VP, Patel, P, Battiston, CD, Hebert, D, Licht, CPB, Piscione, TD & Parekh, RS 2013, 'The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): A prospective cohort study of childhood nephrotic syndrome', BMC Nephrology, vol. 14, no. 1, 25. https://doi.org/10.1186/1471-2369-14-25
Hussain, Neesha ; Zello, J. Anastasia ; Vasilevska-Ristovska, Jovanka ; Banh, Tonny M. ; Patel, Viral P. ; Patel, Pranali ; Battiston, Christopher D. ; Hebert, Diane ; Licht, Christoph P B ; Piscione, Tino D. ; Parekh, Rulan S. / The rationale and design of Insight into Nephrotic Syndrome : Investigating Genes, Health and Therapeutics (INSIGHT): A prospective cohort study of childhood nephrotic syndrome. In: BMC Nephrology. 2013 ; Vol. 14, No. 1.
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abstract = "Background: Nephrotic syndrome is one of the most commonly diagnosed kidney diseases in childhood and its progressive forms can lead to chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There have been few longitudinal studies among a multi-ethnic cohort to determine potential risk factors influencing disease susceptibility, treatment response, and progression of nephrotic syndrome. Temporal relationships cannot be studied through cross-sectional study design. Understanding the interaction between various factors is critical to developing new strategies for treating children with kidney disease. We present the rationale and the study design of a longitudinal cohort study of children with nephrotic syndrome, the Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT) study. The specific aims are to determine: 1) socio-demographic, environmental, and genetic factors that influence disease susceptibility; 2) rates of steroid treatment resistance and steroid treatment dependence, and identify factors that may modify treatment response; 3) clinical and genetic factors that influence disease susceptibility and progression to CKD and ESRD; and 4) the interaction between the course of illness and socio-demographic, environmental, and clinical risk factors. Methods/design. INSIGHT is a disease-based observational longitudinal cohort study of children with nephrotic syndrome. At baseline, participants complete questionnaires and provide biological specimen samples (blood, urine, and toenail clippings). Follow-up questionnaires and repeat biological specimen collections are performed annually for up to five years. Discussion. The proposed cohort will provide the structure to test various risk factors predicting or influencing disease susceptibility, treatment response, and progression to CKD among children with nephrotic syndrome. Trial registration. ClinicalTrials.gov Identifier NCT01605266.",
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AU - Zello, J. Anastasia

AU - Vasilevska-Ristovska, Jovanka

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AU - Patel, Viral P.

AU - Patel, Pranali

AU - Battiston, Christopher D.

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AB - Background: Nephrotic syndrome is one of the most commonly diagnosed kidney diseases in childhood and its progressive forms can lead to chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There have been few longitudinal studies among a multi-ethnic cohort to determine potential risk factors influencing disease susceptibility, treatment response, and progression of nephrotic syndrome. Temporal relationships cannot be studied through cross-sectional study design. Understanding the interaction between various factors is critical to developing new strategies for treating children with kidney disease. We present the rationale and the study design of a longitudinal cohort study of children with nephrotic syndrome, the Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT) study. The specific aims are to determine: 1) socio-demographic, environmental, and genetic factors that influence disease susceptibility; 2) rates of steroid treatment resistance and steroid treatment dependence, and identify factors that may modify treatment response; 3) clinical and genetic factors that influence disease susceptibility and progression to CKD and ESRD; and 4) the interaction between the course of illness and socio-demographic, environmental, and clinical risk factors. Methods/design. INSIGHT is a disease-based observational longitudinal cohort study of children with nephrotic syndrome. At baseline, participants complete questionnaires and provide biological specimen samples (blood, urine, and toenail clippings). Follow-up questionnaires and repeat biological specimen collections are performed annually for up to five years. Discussion. The proposed cohort will provide the structure to test various risk factors predicting or influencing disease susceptibility, treatment response, and progression to CKD among children with nephrotic syndrome. Trial registration. ClinicalTrials.gov Identifier NCT01605266.

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