The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

Caroline R. Weinstein-Oppenheimer, William L. Blalock, Linda S. Steelman, Fumin Chang, James A. McCubrey

Research output: Contribution to journalReview article

Abstract

This review focuses on the Ras-Raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signal transduction pathway and the consequences of its unregulation in the development of cancer. The roles of some of the cell membrane receptors involved in the activation of this pathway, the G-protein Ras, the Raf, MEK and ERK kinases, the phosphatases that regulate these kinases, as well as the downstream transcription factors that become activated, are discussed. The roles of the Ras-Raf-MEK-ERK pathway in the regulation of apoptosis and cell cycle progression are also analyzed. In addition, potential targets for pharmacological intervention in growth factor-responsive cells are evaluated.

Original languageEnglish (US)
Pages (from-to)229-279
Number of pages51
JournalPharmacology and Therapeutics
Volume88
Issue number3
DOIs
StatePublished - Dec 1 2000
Externally publishedYes

Keywords

  • ERK
  • Growth factors
  • MEK
  • Raf
  • Ras
  • Receptors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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