The pulmonary response to a bacteremic challenge.

E. M. Harrow, G. J. Jakab, A. R. Brody, G. M. Green

Research output: Contribution to journalArticle

Abstract

The pulmonary response to a bacteremic challenge was studied in a mouse model. The distribution of intravenously injected radiotracer-labeled Proteus mirabilis and Staphylococcus aureus in the lungs, liver, spleen, kidney, and blood was examined at 0, 5 30, 60, and 240 min. Pulmonary killing of these organisms was studied at 0, 30, and 240 min; 0.8 plus or minus 0.1 per cent of the P. mirabilis and 1.5 plus or minus 0.2 per cent of the S. aureus remained within the lungs after 4 hours. Although only 2.2 plus or minus 0.2 per cent of the P. mirabilis organisms were alive, 33.8 plus or minus 8.8 per cent of the staphylococci remained viable after this period. Light and electron micographs verified that polymorphonuclear leukocytes phagocytized these bacteria. The defense mechanisms of the lung against bloodborne and airborne bacterial infection are functionally, as well as morphologically, distinct.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalAmerican Review of Respiratory Disease
Volume112
Issue number1
StatePublished - Jul 1975
Externally publishedYes

Fingerprint

Proteus mirabilis
Lung
Staphylococcus aureus
Staphylococcus
Bacterial Infections
Neutrophils
Spleen
Electrons
Bacteria
Kidney
Light
Liver

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Harrow, E. M., Jakab, G. J., Brody, A. R., & Green, G. M. (1975). The pulmonary response to a bacteremic challenge. American Review of Respiratory Disease, 112(1), 7-16.

The pulmonary response to a bacteremic challenge. / Harrow, E. M.; Jakab, G. J.; Brody, A. R.; Green, G. M.

In: American Review of Respiratory Disease, Vol. 112, No. 1, 07.1975, p. 7-16.

Research output: Contribution to journalArticle

Harrow, EM, Jakab, GJ, Brody, AR & Green, GM 1975, 'The pulmonary response to a bacteremic challenge.', American Review of Respiratory Disease, vol. 112, no. 1, pp. 7-16.
Harrow EM, Jakab GJ, Brody AR, Green GM. The pulmonary response to a bacteremic challenge. American Review of Respiratory Disease. 1975 Jul;112(1):7-16.
Harrow, E. M. ; Jakab, G. J. ; Brody, A. R. ; Green, G. M. / The pulmonary response to a bacteremic challenge. In: American Review of Respiratory Disease. 1975 ; Vol. 112, No. 1. pp. 7-16.
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