The psychotic phenomenon in probable Alzheimer's disease: A positron emission tomography study

O. L. Lopez, G. Smith, J. T. Becker, C. C. Meltzer, S. T. DeKosky

Research output: Contribution to journalArticlepeer-review

Abstract

Positron emission tomography was used to examine the mechanisms of the psychotic phenomenon in Alzheimer's disease (AD). Data from 2 patients with delusions and 2 with hallucinations were compared with those of 5 AD patients without psychosis. The patients with paranoid delusions had diminished relative regional cerebral blood flow (rel-CBF) in the left dorsolateral prefrontal and left medial temporal cortices. The patients with visual hallucinations showed diminished rel-CBF in the right parietal, left medial temporal, and left dorsolateral prefrontal cortices. These findings support the hypothesis that a frontal-temporal abnormality is associated with paranoid delusions in AD. By contrast, visual hallucinations are associated with parietal as well as frontal and temporal lobe dysfunction. In these patients, a left prefrontal-temporal cortex dysfunction appears to be a common denominator for the development of the psychotic phenomenon in AD.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume13
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The psychotic phenomenon in probable Alzheimer's disease: A positron emission tomography study'. Together they form a unique fingerprint.

Cite this