The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications

Amr A. Youssef, Elsie Gyang Ross, Roberto Bolli, Carl J. Pepine, Nicholas J. Leeper, Phillip C. Yang

Research output: Contribution to journalReview article


The recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. iPSC have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSC, many translational challenges still remain. The authors review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling, and drug discovery. They critically reflect on the current results of pre-clinical and clinical studies using iPSC for these applications with appropriate emphasis on the challenges facing clinical translation.

Original languageEnglish (US)
Pages (from-to)510-523
Number of pages14
JournalJACC: Basic to Translational Science
Issue number6
StatePublished - Oct 1 2016
Externally publishedYes



  • cardiac regeneration
  • disease modeling
  • drug discovery
  • induced pluripotent stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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