The prognostic value of tumor markers in patients with glioblastoma multiforme: Analysis of 32 patients and review of the literature

J. F. Reavey-Cantwell, R. I. Haroun, M. Zahurak, R. E. Clatterbuck, R. J. Parker, R. Mehta, J. P. Fruehauf, H. Brem

Research output: Contribution to journalArticlepeer-review


Although several studies have examined brain tumor markers for prognostic value, few investigations have stratified analysis based on specific histologic grade. The objective of this study was to evaluate a single histologic grade of glioma, the grade IV glioma or glioblastoma (World Health Organization Classification), with a comprehensive panel of tumor markers in an attempt to identify those with prognostic significance. Tumor samples from a cohort of patients with glioblastoma multiforme (n = 32) were examined for tumor markers, DNA analysis, and clinical variables in an attempt to determine a 'profile' for this tumor. We used univariate and multivariate statistical analysis to determine the prognostic value of tumor cell ploidy, percent S-phase, DNA index, p53, and Ki-67 labeling index, as well as the variables of gender, race, age, location of tumor, history of chemotherapy, and primary versus recurrent tumor. Two additional tumor markers, multidrug resistance gene 1 and glutathione-S-transferase subtype pi, were included in the sample testing, but were not analyzed statistically. Univariate analysis indicated that increasing age had a strong association with decreased survival. Female gender, increasing Ki-67, no chemotherapy before sample collection, and primary glioblastoma showed some association with decreased survival in the univariate model. The univariate results indicated that race, side of tumor, ploidy, S-phase, DNA index, and p53 had no prognostic value. Multivariate modeling demonstrated that age, gender, and Ki-67 were the strongest factors associated with survival. The relevant literature is reviewed.

Original languageEnglish (US)
Pages (from-to)195-204
Number of pages10
JournalJournal of neuro-oncology
Issue number3
StatePublished - 2001


  • DNA index
  • Glioblastoma multiforme
  • Glutathione-S-transferase pi
  • Ki-67
  • Multidrug resistance gene 1
  • Ploidy
  • S-phase fraction
  • p53

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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