Abstract
Although several studies have examined brain tumor markers for prognostic value, few investigations have stratified analysis based on specific histologic grade. The objective of this study was to evaluate a single histologic grade of glioma, the grade IV glioma or glioblastoma (World Health Organization Classification), with a comprehensive panel of tumor markers in an attempt to identify those with prognostic significance. Tumor samples from a cohort of patients with glioblastoma multiforme (n = 32) were examined for tumor markers, DNA analysis, and clinical variables in an attempt to determine a 'profile' for this tumor. We used univariate and multivariate statistical analysis to determine the prognostic value of tumor cell ploidy, percent S-phase, DNA index, p53, and Ki-67 labeling index, as well as the variables of gender, race, age, location of tumor, history of chemotherapy, and primary versus recurrent tumor. Two additional tumor markers, multidrug resistance gene 1 and glutathione-S-transferase subtype pi, were included in the sample testing, but were not analyzed statistically. Univariate analysis indicated that increasing age had a strong association with decreased survival. Female gender, increasing Ki-67, no chemotherapy before sample collection, and primary glioblastoma showed some association with decreased survival in the univariate model. The univariate results indicated that race, side of tumor, ploidy, S-phase, DNA index, and p53 had no prognostic value. Multivariate modeling demonstrated that age, gender, and Ki-67 were the strongest factors associated with survival. The relevant literature is reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-204 |
| Number of pages | 10 |
| Journal | Journal of Neuro-Oncology |
| Volume | 55 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- DNA index
- Glioblastoma multiforme
- Glutathione-S-transferase pi
- Ki-67
- Multidrug resistance gene 1
- p53
- Ploidy
- S-phase fraction
ASJC Scopus subject areas
- Clinical Neurology
- Cancer Research
- Oncology
- Neuroscience(all)
Cite this
The prognostic value of tumor markers in patients with glioblastoma multiforme : Analysis of 32 patients and review of the literature. / Reavey-Cantwell, J. F.; Haroun, R. I.; Zahurak, M.; Clatterbuck, R. E.; Parker, R. J.; Mehta, R.; Fruehauf, J. P.; Brem, Henry.
In: Journal of Neuro-Oncology, Vol. 55, No. 3, 2001, p. 195-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The prognostic value of tumor markers in patients with glioblastoma multiforme
T2 - Analysis of 32 patients and review of the literature
AU - Reavey-Cantwell, J. F.
AU - Haroun, R. I.
AU - Zahurak, M.
AU - Clatterbuck, R. E.
AU - Parker, R. J.
AU - Mehta, R.
AU - Fruehauf, J. P.
AU - Brem, Henry
PY - 2001
Y1 - 2001
N2 - Although several studies have examined brain tumor markers for prognostic value, few investigations have stratified analysis based on specific histologic grade. The objective of this study was to evaluate a single histologic grade of glioma, the grade IV glioma or glioblastoma (World Health Organization Classification), with a comprehensive panel of tumor markers in an attempt to identify those with prognostic significance. Tumor samples from a cohort of patients with glioblastoma multiforme (n = 32) were examined for tumor markers, DNA analysis, and clinical variables in an attempt to determine a 'profile' for this tumor. We used univariate and multivariate statistical analysis to determine the prognostic value of tumor cell ploidy, percent S-phase, DNA index, p53, and Ki-67 labeling index, as well as the variables of gender, race, age, location of tumor, history of chemotherapy, and primary versus recurrent tumor. Two additional tumor markers, multidrug resistance gene 1 and glutathione-S-transferase subtype pi, were included in the sample testing, but were not analyzed statistically. Univariate analysis indicated that increasing age had a strong association with decreased survival. Female gender, increasing Ki-67, no chemotherapy before sample collection, and primary glioblastoma showed some association with decreased survival in the univariate model. The univariate results indicated that race, side of tumor, ploidy, S-phase, DNA index, and p53 had no prognostic value. Multivariate modeling demonstrated that age, gender, and Ki-67 were the strongest factors associated with survival. The relevant literature is reviewed.
AB - Although several studies have examined brain tumor markers for prognostic value, few investigations have stratified analysis based on specific histologic grade. The objective of this study was to evaluate a single histologic grade of glioma, the grade IV glioma or glioblastoma (World Health Organization Classification), with a comprehensive panel of tumor markers in an attempt to identify those with prognostic significance. Tumor samples from a cohort of patients with glioblastoma multiforme (n = 32) were examined for tumor markers, DNA analysis, and clinical variables in an attempt to determine a 'profile' for this tumor. We used univariate and multivariate statistical analysis to determine the prognostic value of tumor cell ploidy, percent S-phase, DNA index, p53, and Ki-67 labeling index, as well as the variables of gender, race, age, location of tumor, history of chemotherapy, and primary versus recurrent tumor. Two additional tumor markers, multidrug resistance gene 1 and glutathione-S-transferase subtype pi, were included in the sample testing, but were not analyzed statistically. Univariate analysis indicated that increasing age had a strong association with decreased survival. Female gender, increasing Ki-67, no chemotherapy before sample collection, and primary glioblastoma showed some association with decreased survival in the univariate model. The univariate results indicated that race, side of tumor, ploidy, S-phase, DNA index, and p53 had no prognostic value. Multivariate modeling demonstrated that age, gender, and Ki-67 were the strongest factors associated with survival. The relevant literature is reviewed.
KW - DNA index
KW - Glioblastoma multiforme
KW - Glutathione-S-transferase pi
KW - Ki-67
KW - Multidrug resistance gene 1
KW - p53
KW - Ploidy
KW - S-phase fraction
UR - http://www.scopus.com/inward/record.url?scp=0035712570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035712570&partnerID=8YFLogxK
U2 - 10.1023/A:1013845004294
DO - 10.1023/A:1013845004294
M3 - Article
C2 - 11859975
AN - SCOPUS:0035712570
VL - 55
SP - 195
EP - 204
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 3
ER -