The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma

Lauren M. Postlewait; Malcolm H. Squires; David A. Kooby; George A. Poultsides; Sharon M. Weber; Mark Bloomston; Ryan C. Fields; Timothy M. Pawlik; Konstantinos I. Votanopoulos; Carl R. Schmidt; Aslam Ejaz; Alexandra W. Acher; David J. Worhunsky; Neil Saunders; Douglas Swords; Linda X. Jin; Clifford S. Cho; Emily R. Winslow; Kenneth Cardona; Charles A. Staley; Shishir K. Maithel

doi:10.1245/s10434-015-4724-8

The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma

Lauren M. Postlewait, Malcolm H. Squires, David A. Kooby, George A. Poultsides, Sharon M. Weber, Mark Bloomston, Ryan C. Fields, Timothy M. Pawlik, Konstantinos I. Votanopoulos, Carl R. Schmidt, Aslam Ejaz, Alexandra W. Acher, David J. Worhunsky, Neil Saunders, Douglas Swords, Linda X. Jin, Clifford S. Cho, Emily R. Winslow, Kenneth Cardona, Charles A. StaleyShishir K. Maithel

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Conflicting data exist on the prognostic implication of signet-ring cell (SRC) histology in gastric adenocarcinoma (GAC). Methods: All patients who underwent curative-intent resection of GAC from the seven institutions of the U.S. Gastric Cancer Collaborative between 2000 and 2012 were included. Primary end points were recurrence-free survival (RFS) and overall survival (OS). Stage-specific analyses were performed. Results: A total of 768 patients met the inclusion criteria. SRC was present in 40.6 % of patients and was associated with female sex (52.9 vs. 38.6 %; p

Original language	English (US)
Pages (from-to)	832-839
Number of pages	8
Journal	Annals of Surgical Oncology
Volume	22
DOIs	https://doi.org/10.1245/s10434-015-4724-8
State	Published - Dec 1 2015

ASJC Scopus subject areas

Surgery
Oncology

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10.1245/s10434-015-4724-8

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Postlewait, L. M., Squires, M. H., Kooby, D. A., Poultsides, G. A., Weber, S. M., Bloomston, M., Fields, R. C., Pawlik, T. M., Votanopoulos, K. I., Schmidt, C. R., Ejaz, A., Acher, A. W., Worhunsky, D. J., Saunders, N., Swords, D., Jin, L. X., Cho, C. S., Winslow, E. R., Cardona, K., ... Maithel, S. K. (2015). The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma. Annals of Surgical Oncology, 22, 832-839. https://doi.org/10.1245/s10434-015-4724-8

Postlewait, LM, Squires, MH, Kooby, DA, Poultsides, GA, Weber, SM, Bloomston, M, Fields, RC, Pawlik, TM, Votanopoulos, KI, Schmidt, CR, Ejaz, A, Acher, AW, Worhunsky, DJ, Saunders, N, Swords, D, Jin, LX, Cho, CS, Winslow, ER, Cardona, K, Staley, CA & Maithel, SK 2015, 'The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma', Annals of Surgical Oncology, vol. 22, pp. 832-839. https://doi.org/10.1245/s10434-015-4724-8

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title = "The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma",

abstract = "Background: Conflicting data exist on the prognostic implication of signet-ring cell (SRC) histology in gastric adenocarcinoma (GAC). Methods: All patients who underwent curative-intent resection of GAC from the seven institutions of the U.S. Gastric Cancer Collaborative between 2000 and 2012 were included. Primary end points were recurrence-free survival (RFS) and overall survival (OS). Stage-specific analyses were performed. Results: A total of 768 patients met the inclusion criteria. SRC was present in 40.6 % of patients and was associated with female sex (52.9 vs. 38.6 %; p ",

author = "Postlewait, {Lauren M.} and Squires, {Malcolm H.} and Kooby, {David A.} and Poultsides, {George A.} and Weber, {Sharon M.} and Mark Bloomston and Fields, {Ryan C.} and Pawlik, {Timothy M.} and Votanopoulos, {Konstantinos I.} and Schmidt, {Carl R.} and Aslam Ejaz and Acher, {Alexandra W.} and Worhunsky, {David J.} and Neil Saunders and Douglas Swords and Jin, {Linda X.} and Cho, {Clifford S.} and Winslow, {Emily R.} and Kenneth Cardona and Staley, {Charles A.} and Maithel, {Shishir K.}",

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doi = "10.1245/s10434-015-4724-8",

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T1 - The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma

AU - Postlewait, Lauren M.

AU - Squires, Malcolm H.

AU - Kooby, David A.

AU - Poultsides, George A.

AU - Weber, Sharon M.

AU - Bloomston, Mark

AU - Fields, Ryan C.

AU - Pawlik, Timothy M.

AU - Votanopoulos, Konstantinos I.

AU - Schmidt, Carl R.

AU - Ejaz, Aslam

AU - Acher, Alexandra W.

AU - Worhunsky, David J.

AU - Saunders, Neil

AU - Swords, Douglas

AU - Jin, Linda X.

AU - Cho, Clifford S.

AU - Winslow, Emily R.

AU - Cardona, Kenneth

AU - Staley, Charles A.

AU - Maithel, Shishir K.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: Conflicting data exist on the prognostic implication of signet-ring cell (SRC) histology in gastric adenocarcinoma (GAC). Methods: All patients who underwent curative-intent resection of GAC from the seven institutions of the U.S. Gastric Cancer Collaborative between 2000 and 2012 were included. Primary end points were recurrence-free survival (RFS) and overall survival (OS). Stage-specific analyses were performed. Results: A total of 768 patients met the inclusion criteria. SRC was present in 40.6 % of patients and was associated with female sex (52.9 vs. 38.6 %; p

AB - Background: Conflicting data exist on the prognostic implication of signet-ring cell (SRC) histology in gastric adenocarcinoma (GAC). Methods: All patients who underwent curative-intent resection of GAC from the seven institutions of the U.S. Gastric Cancer Collaborative between 2000 and 2012 were included. Primary end points were recurrence-free survival (RFS) and overall survival (OS). Stage-specific analyses were performed. Results: A total of 768 patients met the inclusion criteria. SRC was present in 40.6 % of patients and was associated with female sex (52.9 vs. 38.6 %; p

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The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma

Abstract

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