The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels

D. B. Reuben, L. Ferrucci, R. Wallace, R. P. Tracy, M. C. Corti, H. Heimovitz, T. B. Harris

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: We sought to determine the prognostic value of serum albumin for 4-year mortality among high-functioning persons who did or did not have evidence of inflammation as indicated by high interleukin-6 (IL-6) levels. DESIGN: We used a case-cohort design of healthy, nondisabled older persons who had serum albumin and plasma IL-6 measured at baseline. Crude and multiply adjusted (for sociodemographics and chronic diseases) proportional hazards models were used to identify the effect of baseline levels of serum albumin level on 4-year mortality among those with higher and lower levels of IL-6. RESULTS: Among subjects without evidence of IL-6-mediated inflammation (IL-6 <3.20 pg/mL), having a lower (≤ 4.4 g/dL) albumin level was associated with a multiply adjusted relative risk of 2.1 for 4-year mortality compared with those wish higher albumin. In the presence of inflammation (IL-6 ≥ 3.20 pg/mL), higher and lower serum albumin levels had similar risks (adjusted relative risks 4.0 and 3.8, respectively) compared with the referent group (higher albumin and low IL-6). CONCLUSIONS: High serum albumin has a protective effect in healthy older persons who do not have evidence of cytokine-mediated inflammation. This protective effect is not conferred in presence of inflammation. The mechanisms by which inflammation eliminates the protective effect of high albumin remain to be determined.

Original languageEnglish (US)
Pages (from-to)1404-1407
Number of pages4
JournalJournal of the American Geriatrics Society
Volume48
Issue number11
StatePublished - 2000
Externally publishedYes

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Serum Albumin
Interleukin-6
Inflammation
Serum
Albumins
Mortality
Proportional Hazards Models
Chronic Disease
Cytokines

Keywords

  • Albumin
  • Cytokines
  • Inflammation
  • Interleukin-6
  • Malnutrition

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Reuben, D. B., Ferrucci, L., Wallace, R., Tracy, R. P., Corti, M. C., Heimovitz, H., & Harris, T. B. (2000). The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. Journal of the American Geriatrics Society, 48(11), 1404-1407.

The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. / Reuben, D. B.; Ferrucci, L.; Wallace, R.; Tracy, R. P.; Corti, M. C.; Heimovitz, H.; Harris, T. B.

In: Journal of the American Geriatrics Society, Vol. 48, No. 11, 2000, p. 1404-1407.

Research output: Contribution to journalArticle

Reuben, DB, Ferrucci, L, Wallace, R, Tracy, RP, Corti, MC, Heimovitz, H & Harris, TB 2000, 'The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels', Journal of the American Geriatrics Society, vol. 48, no. 11, pp. 1404-1407.
Reuben, D. B. ; Ferrucci, L. ; Wallace, R. ; Tracy, R. P. ; Corti, M. C. ; Heimovitz, H. ; Harris, T. B. / The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. In: Journal of the American Geriatrics Society. 2000 ; Vol. 48, No. 11. pp. 1404-1407.
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AU - Tracy, R. P.

AU - Corti, M. C.

AU - Heimovitz, H.

AU - Harris, T. B.

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AB - OBJECTIVE: We sought to determine the prognostic value of serum albumin for 4-year mortality among high-functioning persons who did or did not have evidence of inflammation as indicated by high interleukin-6 (IL-6) levels. DESIGN: We used a case-cohort design of healthy, nondisabled older persons who had serum albumin and plasma IL-6 measured at baseline. Crude and multiply adjusted (for sociodemographics and chronic diseases) proportional hazards models were used to identify the effect of baseline levels of serum albumin level on 4-year mortality among those with higher and lower levels of IL-6. RESULTS: Among subjects without evidence of IL-6-mediated inflammation (IL-6 <3.20 pg/mL), having a lower (≤ 4.4 g/dL) albumin level was associated with a multiply adjusted relative risk of 2.1 for 4-year mortality compared with those wish higher albumin. In the presence of inflammation (IL-6 ≥ 3.20 pg/mL), higher and lower serum albumin levels had similar risks (adjusted relative risks 4.0 and 3.8, respectively) compared with the referent group (higher albumin and low IL-6). CONCLUSIONS: High serum albumin has a protective effect in healthy older persons who do not have evidence of cytokine-mediated inflammation. This protective effect is not conferred in presence of inflammation. The mechanisms by which inflammation eliminates the protective effect of high albumin remain to be determined.

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