The prognostic value of histological grading of posterior fossa ependymomas in children: A Children's Oncology Group study and a review of prognostic factors

Tarik Tihan, Tianni Zhou, Emi Holmes, Peter C. Burger, Sema Ozuysal, Elisabeth J. Rushing

Research output: Contribution to journalArticle

Abstract

We performed a retrospective analysis of 96 pediatric posterior fossa ependymomas in order to determine the prognostic value of histological grade based on the current WHO grading scheme. The patients were selected among Children's Oncology Group (previously Pediatric Oncology Group-POG) patients enrolled in clinical trials, and on the basis of central pathology review, location, and age. We excluded entities such as sub-ependymoma, myxopapillary, or clear-cell ependymoma, after a consensus diagnosis by three neuropathologists. A total of 66 males and 30 females with a median age of 48 months were identified. The group was analyzed to determine the effects of histological grade, age, gender, and extent of resection on event-free and overall survival. Our results showed that extent of resection, age, and histological grade were independent prognostic variables for event-free survival. The relative risk for extent of resection and histological grade was calculated as 3.59 (P

Original languageEnglish (US)
Pages (from-to)165-177
Number of pages13
JournalModern Pathology
Volume21
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

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Ependymoma
Disease-Free Survival
Pediatrics
Clinical Trials
Pathology

Keywords

  • Childhood brain tumor
  • Ependymoma
  • Posterior fossa
  • Prognosis
  • Review pediatric glioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The prognostic value of histological grading of posterior fossa ependymomas in children : A Children's Oncology Group study and a review of prognostic factors. / Tihan, Tarik; Zhou, Tianni; Holmes, Emi; Burger, Peter C.; Ozuysal, Sema; Rushing, Elisabeth J.

In: Modern Pathology, Vol. 21, No. 2, 02.2008, p. 165-177.

Research output: Contribution to journalArticle

Tihan, Tarik ; Zhou, Tianni ; Holmes, Emi ; Burger, Peter C. ; Ozuysal, Sema ; Rushing, Elisabeth J. / The prognostic value of histological grading of posterior fossa ependymomas in children : A Children's Oncology Group study and a review of prognostic factors. In: Modern Pathology. 2008 ; Vol. 21, No. 2. pp. 165-177.
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