The prognostic value of age for invasive lobular breast cancer depending on estrogen receptor and progesterone receptordefined subtypes: A NCDB analysis

Jieqiong Liu, Kai Chen, Kai Mao, Fengxi Su, Qiang Liu, Lisa Jacobs

Research output: Contribution to journalArticle

Abstract

Purpose: We aimed to assess the effect of age on survival according to estrogen receptor (ER) and progesterone receptor (PR)-defined lobular breast cancer subtype in a wide age range. Methods: 43,230 invasive lobular breast cancer women without comorbidities diagnosed between 2004 and 2011 in the National Cancer Database (NCDB) were analyzed. The effects of age on overall survival (OS) among different age groups were evaluated by log-rank test and Cox proportional model. Results: Multivariate analysis showed that patients diagnosed at both young ( 0.1); and in ER-PR+ subgroup, the HRs were similar in patients younger than 70 (P > 0.1); thus, the plots of HRs in these three subtypes remained steady until the age of 60 or 70. Conclusions: Our findings identified that the effect of age on OS in lobular breast cancer varied with ER/PR-defined subtypes. Personalized treatment strategies should be developed to improve outcomes of breast cancer patients with different ages and ER/PR statuses.

Original languageEnglish (US)
Pages (from-to)6063-6073
Number of pages11
JournalOncotarget
Volume7
Issue number5
DOIs
StatePublished - 2016

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Progesterone Receptors
Estrogen Receptors
Progesterone
Databases
Breast Neoplasms
Survival
Neoplasms
Proportional Hazards Models
Comorbidity
Multivariate Analysis
Age Groups
Therapeutics

Keywords

  • Age
  • ER/PR-defined subtypes
  • Lobular breast cancer
  • National cancer database
  • Prognostic value

ASJC Scopus subject areas

  • Oncology

Cite this

The prognostic value of age for invasive lobular breast cancer depending on estrogen receptor and progesterone receptordefined subtypes : A NCDB analysis. / Liu, Jieqiong; Chen, Kai; Mao, Kai; Su, Fengxi; Liu, Qiang; Jacobs, Lisa.

In: Oncotarget, Vol. 7, No. 5, 2016, p. 6063-6073.

Research output: Contribution to journalArticle

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