The prognostic value of adipose tissue fatty acids for incident cardiovascular disease: Results from 3944 subjects in the Scottish Heart Health Extended Cohort Study

Mark Woodward, Hugh Tunstall-Pedoe, G. David Batty, Roger Tavendale, Frank B. Hu, Sébastien Czernichow

Research output: Contribution to journalArticle

Abstract

Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods and resultsAdipose tissue was taken from 3944 participants, predominantly aged 4059 years, in Scotland, 198487. Percentages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95 confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4, respectively, with only the latter being significant at the 5 level. Conclusion sA diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.

Original languageEnglish (US)
Pages (from-to)1416-1423
Number of pages8
JournalEuropean Heart Journal
Volume32
Issue number11
DOIs
StatePublished - Jun 2011

Fingerprint

Adipose Tissue
Cohort Studies
Cardiovascular Diseases
Fatty Acids
Health
Fats
Diet
Blood Pressure
Dietary Fats
Scotland
Proportional Hazards Models
Gas Chromatography
HDL Cholesterol
Smoking
Odds Ratio
Economics
Prospective Studies
Confidence Intervals
Population

Keywords

  • Fatty acids
  • Myocardial infarction
  • Risk score
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The prognostic value of adipose tissue fatty acids for incident cardiovascular disease : Results from 3944 subjects in the Scottish Heart Health Extended Cohort Study. / Woodward, Mark; Tunstall-Pedoe, Hugh; Batty, G. David; Tavendale, Roger; Hu, Frank B.; Czernichow, Sébastien.

In: European Heart Journal, Vol. 32, No. 11, 06.2011, p. 1416-1423.

Research output: Contribution to journalArticle

Woodward, Mark ; Tunstall-Pedoe, Hugh ; Batty, G. David ; Tavendale, Roger ; Hu, Frank B. ; Czernichow, Sébastien. / The prognostic value of adipose tissue fatty acids for incident cardiovascular disease : Results from 3944 subjects in the Scottish Heart Health Extended Cohort Study. In: European Heart Journal. 2011 ; Vol. 32, No. 11. pp. 1416-1423.
@article{fe77ad4311f24f05b432e0da8c40ce67,
title = "The prognostic value of adipose tissue fatty acids for incident cardiovascular disease: Results from 3944 subjects in the Scottish Heart Health Extended Cohort Study",
abstract = "Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods and resultsAdipose tissue was taken from 3944 participants, predominantly aged 4059 years, in Scotland, 198487. Percentages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95 confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4, respectively, with only the latter being significant at the 5 level. Conclusion sA diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.",
keywords = "Fatty acids, Myocardial infarction, Risk score, Stroke",
author = "Mark Woodward and Hugh Tunstall-Pedoe and Batty, {G. David} and Roger Tavendale and Hu, {Frank B.} and S{\'e}bastien Czernichow",
year = "2011",
month = "6",
doi = "10.1093/eurheartj/ehr036",
language = "English (US)",
volume = "32",
pages = "1416--1423",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - The prognostic value of adipose tissue fatty acids for incident cardiovascular disease

T2 - Results from 3944 subjects in the Scottish Heart Health Extended Cohort Study

AU - Woodward, Mark

AU - Tunstall-Pedoe, Hugh

AU - Batty, G. David

AU - Tavendale, Roger

AU - Hu, Frank B.

AU - Czernichow, Sébastien

PY - 2011/6

Y1 - 2011/6

N2 - Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods and resultsAdipose tissue was taken from 3944 participants, predominantly aged 4059 years, in Scotland, 198487. Percentages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95 confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4, respectively, with only the latter being significant at the 5 level. Conclusion sA diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.

AB - Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods and resultsAdipose tissue was taken from 3944 participants, predominantly aged 4059 years, in Scotland, 198487. Percentages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95 confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4, respectively, with only the latter being significant at the 5 level. Conclusion sA diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.

KW - Fatty acids

KW - Myocardial infarction

KW - Risk score

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=79958112648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958112648&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehr036

DO - 10.1093/eurheartj/ehr036

M3 - Article

C2 - 21345851

AN - SCOPUS:79958112648

VL - 32

SP - 1416

EP - 1423

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 11

ER -