TY - JOUR
T1 - The Prognostic Significance of Measurable (“Minimal”) Residual Disease in Acute Myeloid Leukemia
AU - Buccisano, Francesco
AU - Hourigan, Christopher S.
AU - Walter, Roland B.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose of Review: The purpose of this review was to evaluate recent literature on detection methodologies for, and prognostic significance of, measurable (“minimal”) residual disease (MRD) in acute myeloid leukemia (AML). Recent Findings: There is no “one-fits-all” approach to MRD testing in AML. Most exploited to date are methods relying on immunophenotypic aberrancies (identified via multiparameter flow cytometry) or genetic abnormalities (identified via PCR-based assays). Current methods have important shortcomings, including the lack of assay platform standardization/harmonization across laboratories. In parallel to refinements of existing technologies and data analysis/interpretation, new methodologies (e.g., next-generation sequencing-based assays) are emerging that eventually may complement or replace existing ones. Summary: This dynamic evolution of MRD testing has complicated comparisons between individual studies. Nonetheless, an ever-growing body of data demonstrates that a positive MRD test at various time points throughout chemotherapy and hematopoietic cell transplantation identifies patients at particularly high risks of disease recurrence and short survival even after adjustment for other risk factors.
AB - Purpose of Review: The purpose of this review was to evaluate recent literature on detection methodologies for, and prognostic significance of, measurable (“minimal”) residual disease (MRD) in acute myeloid leukemia (AML). Recent Findings: There is no “one-fits-all” approach to MRD testing in AML. Most exploited to date are methods relying on immunophenotypic aberrancies (identified via multiparameter flow cytometry) or genetic abnormalities (identified via PCR-based assays). Current methods have important shortcomings, including the lack of assay platform standardization/harmonization across laboratories. In parallel to refinements of existing technologies and data analysis/interpretation, new methodologies (e.g., next-generation sequencing-based assays) are emerging that eventually may complement or replace existing ones. Summary: This dynamic evolution of MRD testing has complicated comparisons between individual studies. Nonetheless, an ever-growing body of data demonstrates that a positive MRD test at various time points throughout chemotherapy and hematopoietic cell transplantation identifies patients at particularly high risks of disease recurrence and short survival even after adjustment for other risk factors.
KW - Acute myeloid leukemia
KW - Flow cytometry
KW - Minimal residual disease
KW - Next-generation sequencing
KW - Polymerase chain reaction
KW - Prognostication
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U2 - 10.1007/s11899-017-0420-z
DO - 10.1007/s11899-017-0420-z
M3 - Review article
C2 - 29027628
AN - SCOPUS:85031424701
SN - 1558-8211
VL - 12
SP - 547
EP - 556
JO - Current Hematologic Malignancy Reports
JF - Current Hematologic Malignancy Reports
IS - 6
ER -