The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study

Marjolijn B. Verbruggen; Paul J. Van Diest; Jan P. Baak; Mark A M Broeckaert; Peter Kenemans; René H M Verheijen

doi:10.1097/PGP.0b013e31818131ff

The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study

Marjolijn B. Verbruggen, Paul J. Van Diest, Jan P. Baak, Mark A M Broeckaert, Peter Kenemans, René H M Verheijen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

To evaluate if morphometric features (mitotic activity index, volume percentage of epithelium, and DNA ploidy) are prognostic markers in borderline ovarian tumors (BOTs). Ninety-three serous and mucinous consecutive BOTs diagnosed between 1989 and 2002 were studied. In all tumors, mitotic activity index, volume percentage of epithelium, and DNA ploidy were determined prospectively. Consecutively, age at diagnosis, calculated tumor volume, International Federation of Gynecology and Obstetrics (FIGO) stage, and treatment by extensive staging were evaluated after a median follow-up of 52 months. Serous BOTs presented at a younger age (P

Original language	English (US)
Pages (from-to)	35-40
Number of pages	6
Journal	International Journal of Gynecological Pathology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1097/PGP.0b013e31818131ff
State	Published - Jan 2009
Externally published	Yes

Keywords

Borderline ovarian tumor
Cytometry
Mitotic activity index (MAI)
Morphometry
Prognostic factors
Volume percentage of epithelium (VPE)

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynecology
Medicine(all)

Access to Document

10.1097/PGP.0b013e31818131ff

Cite this

@article{f9146fb21208486bb4a33cc6ca921ae3,

title = "The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study",

abstract = "To evaluate if morphometric features (mitotic activity index, volume percentage of epithelium, and DNA ploidy) are prognostic markers in borderline ovarian tumors (BOTs). Ninety-three serous and mucinous consecutive BOTs diagnosed between 1989 and 2002 were studied. In all tumors, mitotic activity index, volume percentage of epithelium, and DNA ploidy were determined prospectively. Consecutively, age at diagnosis, calculated tumor volume, International Federation of Gynecology and Obstetrics (FIGO) stage, and treatment by extensive staging were evaluated after a median follow-up of 52 months. Serous BOTs presented at a younger age (P",

keywords = "Borderline ovarian tumor, Cytometry, Mitotic activity index (MAI), Morphometry, Prognostic factors, Volume percentage of epithelium (VPE)",

author = "Verbruggen, {Marjolijn B.} and {Van Diest}, {Paul J.} and Baak, {Jan P.} and Broeckaert, {Mark A M} and Peter Kenemans and Verheijen, {Ren{\'e} H M}",

year = "2009",

month = jan,

doi = "10.1097/PGP.0b013e31818131ff",

language = "English (US)",

volume = "28",

pages = "35--40",

journal = "International Journal of Gynecological Pathology",

issn = "0277-1691",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors

T2 - A prospective study

AU - Verbruggen, Marjolijn B.

AU - Van Diest, Paul J.

AU - Baak, Jan P.

AU - Broeckaert, Mark A M

AU - Kenemans, Peter

AU - Verheijen, René H M

PY - 2009/1

Y1 - 2009/1

N2 - To evaluate if morphometric features (mitotic activity index, volume percentage of epithelium, and DNA ploidy) are prognostic markers in borderline ovarian tumors (BOTs). Ninety-three serous and mucinous consecutive BOTs diagnosed between 1989 and 2002 were studied. In all tumors, mitotic activity index, volume percentage of epithelium, and DNA ploidy were determined prospectively. Consecutively, age at diagnosis, calculated tumor volume, International Federation of Gynecology and Obstetrics (FIGO) stage, and treatment by extensive staging were evaluated after a median follow-up of 52 months. Serous BOTs presented at a younger age (P

AB - To evaluate if morphometric features (mitotic activity index, volume percentage of epithelium, and DNA ploidy) are prognostic markers in borderline ovarian tumors (BOTs). Ninety-three serous and mucinous consecutive BOTs diagnosed between 1989 and 2002 were studied. In all tumors, mitotic activity index, volume percentage of epithelium, and DNA ploidy were determined prospectively. Consecutively, age at diagnosis, calculated tumor volume, International Federation of Gynecology and Obstetrics (FIGO) stage, and treatment by extensive staging were evaluated after a median follow-up of 52 months. Serous BOTs presented at a younger age (P

KW - Borderline ovarian tumor

KW - Cytometry

KW - Mitotic activity index (MAI)

KW - Morphometry

KW - Prognostic factors

KW - Volume percentage of epithelium (VPE)

UR - http://www.scopus.com/inward/record.url?scp=61449522286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61449522286&partnerID=8YFLogxK

U2 - 10.1097/PGP.0b013e31818131ff

DO - 10.1097/PGP.0b013e31818131ff

M3 - Article

C2 - 19047910

AN - SCOPUS:61449522286

SN - 0277-1691

VL - 28

SP - 35

EP - 40

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

IS - 1

ER -

The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this