The prognostic and clinical value of morphometry and DNA cytometry in borderline ovarian tumors: A prospective study

Marjolijn B. Verbruggen, Paul J. Van Diest, Jan P. Baak, Mark A M Broeckaert, Peter Kenemans, René H M Verheijen

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate if morphometric features (mitotic activity index, volume percentage of epithelium, and DNA ploidy) are prognostic markers in borderline ovarian tumors (BOTs). Ninety-three serous and mucinous consecutive BOTs diagnosed between 1989 and 2002 were studied. In all tumors, mitotic activity index, volume percentage of epithelium, and DNA ploidy were determined prospectively. Consecutively, age at diagnosis, calculated tumor volume, International Federation of Gynecology and Obstetrics (FIGO) stage, and treatment by extensive staging were evaluated after a median follow-up of 52 months. Serous BOTs presented at a younger age (P

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Keywords

  • Borderline ovarian tumor
  • Cytometry
  • Mitotic activity index (MAI)
  • Morphometry
  • Prognostic factors
  • Volume percentage of epithelium (VPE)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology
  • Medicine(all)

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