The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: A study of calcitonin, L-dopa decarboxylase, and histaminase

S. M. Lippman, G. Mendelsohn, D. L. Trump, S. A. Wells, Stephen B Baylin

Research output: Contribution to journalArticle

Abstract

We evaluated the cellular distribution of calcitonin (CT), L-dopa decarboxylase (DDC), and histaminase [diamine oxidase (DAO)] in 33 patients with medullary thyroid carcinoma (MTC). CT-immunostaining was uniform (>90% of the cells) and intense (4+) in lesions from 7 patients with C-cell hyperplasia and 6 with microscopic MTC: conversely, patchy CT staining (90%) in 11 subjects who were well 0.5-16 yr postoperatively. Six patients with similar clinical presentations had heterogenous staining for CT in primary tumor (

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number2
StatePublished - 1982

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Dopa Decarboxylase
Amine Oxidase (Copper-Containing)
Calcitonin
Levodopa
Staining and Labeling
Hyperplasia
Tumors
Medullary Thyroid cancer
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma : A study of calcitonin, L-dopa decarboxylase, and histaminase. / Lippman, S. M.; Mendelsohn, G.; Trump, D. L.; Wells, S. A.; Baylin, Stephen B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 54, No. 2, 1982, p. 233-240.

Research output: Contribution to journalArticle

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