The Problem of Neurovascular Uncoupling

Shruti Agarwal; Haris I. Sair; Jay J. Pillai

doi:10.1016/j.nic.2020.09.003

The Problem of Neurovascular Uncoupling

Shruti Agarwal, Haris I. Sair, Jay J. Pillai

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.

Original language	English (US)
Pages (from-to)	53-67
Number of pages	15
Journal	Neuroimaging Clinics of North America
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.nic.2020.09.003
State	Published - Feb 2021

Keywords

Motor activation
Neurovascular uncoupling
Presurgical mapping

ASJC Scopus subject areas

Clinical Neurology
Radiology Nuclear Medicine and imaging

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10.1016/j.nic.2020.09.003

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title = "The Problem of Neurovascular Uncoupling",

abstract = "Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.",

keywords = "Motor activation, Neurovascular uncoupling, Presurgical mapping",

author = "Shruti Agarwal and Sair, {Haris I.} and Pillai, {Jay J.}",

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year = "2021",

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AU - Pillai, Jay J.

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N2 - Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.

AB - Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.

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KW - Presurgical mapping

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The Problem of Neurovascular Uncoupling

Abstract

Keywords

ASJC Scopus subject areas

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