The problem of amino acid complementarity and antisense peptides

Ignacy Z. Siemion, Marek Cebrat, Alicja Kluczyk

Research output: Contribution to journalArticle

Abstract

The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and anti-amino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis resulting from the periodicity of the genetic code. The current state of knowledge as well as the results of the implementations of these hypotheses are compared. A special attention is given to Root-Bernstein and Siemion hypotheses, which differ in only few points of the complementarity prediction. We describe methods of investigation of peptide - antipeptide pairing, including circular dichroism, mass spectrometry, affinity chromatography and other techniques. The biological applications of complementarity principle are considered, such as search for bioeffector - bioreceptor interaction systems, the influence of peptide - antipeptide pairing on the activity of peptide hormones, and the application of antipeptides in immunochemistry. The possible role of amino acid - anti-amino acid interactions in the formation of the spatial structures of peptides, proteins and protein complexes is discussed. Such problems as the pairing preferences of protein - protein interfaces, the role of the pairing in the creation of disulfide bonds and the possible appearance of such interactions in β-structure are also examined. The main intention of the paper is to bring the complementarity problem to the attention of the scientific community, as a possible tool in proteomics, molecular design and molecular recognition.

Original languageEnglish (US)
Pages (from-to)507-527
Number of pages21
JournalCurrent Protein and Peptide Science
Volume5
Issue number6
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Amino Acids
Peptides
Proteins
Genetic Code
Immunochemistry
Anticodon
Affinity chromatography
Molecular recognition
Peptide Hormones
Dichroism
Periodicity
Circular Dichroism
Affinity Chromatography
Disulfides
Proteomics
Mass spectrometry
Mass Spectrometry
DNA

Keywords

  • Antiidiotypic antibodies
  • Antipeptides
  • Antisense peptides
  • Complementary peptides
  • Hydropathic complementarity

ASJC Scopus subject areas

  • Biochemistry

Cite this

The problem of amino acid complementarity and antisense peptides. / Siemion, Ignacy Z.; Cebrat, Marek; Kluczyk, Alicja.

In: Current Protein and Peptide Science, Vol. 5, No. 6, 12.2004, p. 507-527.

Research output: Contribution to journalArticle

Siemion, Ignacy Z. ; Cebrat, Marek ; Kluczyk, Alicja. / The problem of amino acid complementarity and antisense peptides. In: Current Protein and Peptide Science. 2004 ; Vol. 5, No. 6. pp. 507-527.
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