The prevention and regression of atherosclerotic plaques: Emerging treatments

Atul Ashok Kalanuria, Paul Nyquist, Geoffrey Ling

Research output: Contribution to journalReview article

Abstract

Occlusive vascular diseases, such as sudden coronary syndromes, stroke, and peripheral arterial disease, are a huge burden on the health care systems of developed and developing countries. Tremendous advances have been made over the last few decades in the diagnosis and treatment of atherosclerotic diseases. Intravascular ultrasound has been able to provide detailed information of plaque anatomy and has been used in several studies to assess outcomes. The presence of atherosclerosis disrupts the normal protective mechanism provided by the endothelium and this mechanism has been implicated in the pathophysiology of coronary artery disease and stroke. Efforts are being put into the prevention of atherosclerosis, which has been shown to begin in childhood. This paper reviews the pathophysiology of atherosclerosis and discusses the current options available for the prevention and reversal of plaque formation.

Original languageEnglish (US)
Pages (from-to)549-561
Number of pages13
JournalVascular health and risk management
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2012

Keywords

  • Atherosclerotic disease
  • Cardiovascular
  • Coronary artery disease
  • Endothelium
  • Plaque
  • Reversal
  • Stroke

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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