TY - JOUR
T1 - The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease
T2 - The Brazilian study on healthy aging
AU - Roberson, Lara
AU - Shaharyar, Sameer
AU - Aneni, Ehimen
AU - Freitas, Wladimir
AU - Blaha, Michael
AU - Agatston, Arthur
AU - Blumenthal, Roger
AU - Santos, Raul D.
AU - Feiz, Hamid
AU - Nasir, Khurram
AU - Sposito, Andrei
N1 - Publisher Copyright:
© 2014 Roberson et al.
PY - 2014/11/7
Y1 - 2014/11/7
N2 - Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.
AB - Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.
KW - Aging
KW - Metabolic Syndrome
KW - Obesity
KW - Subclinical CVD
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U2 - 10.1186/1758-5996-6-121
DO - 10.1186/1758-5996-6-121
M3 - Article
AN - SCOPUS:84920837815
SN - 1758-5996
VL - 6
JO - Diabetology and Metabolic Syndrome
JF - Diabetology and Metabolic Syndrome
IS - 1
M1 - 121
ER -