The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease

The Brazilian study on healthy aging

Lara Roberson, Sameer Shaharyar, Ehimen Aneni, Wladimir Freitas, Michael Blaha, Arthur Agatston, Roger S Blumenthal, Raul D. Santos, Hamid Feiz, Khurram Nasir, Andrei Sposito

Research output: Contribution to journalArticle

Abstract

Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and Methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.

Original languageEnglish (US)
Pages (from-to)121
Number of pages1
JournalDiabetology and Metabolic Syndrome
DOIs
StateAccepted/In press - Nov 7 2014

Fingerprint

Cardiovascular Diseases
Phenotype
Population
Coronary Vessels
Research Design
Obesity
Cross-Sectional Studies
Adenosine Triphosphate
Cholesterol
Calcium
Education
Weights and Measures
Health
Therapeutics

Keywords

  • Aging
  • Metabolic Syndrome
  • Obesity
  • Subclinical CVD

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease : The Brazilian study on healthy aging. / Roberson, Lara; Shaharyar, Sameer; Aneni, Ehimen; Freitas, Wladimir; Blaha, Michael; Agatston, Arthur; Blumenthal, Roger S; Santos, Raul D.; Feiz, Hamid; Nasir, Khurram; Sposito, Andrei.

In: Diabetology and Metabolic Syndrome, 07.11.2014, p. 121.

Research output: Contribution to journalArticle

Roberson, Lara ; Shaharyar, Sameer ; Aneni, Ehimen ; Freitas, Wladimir ; Blaha, Michael ; Agatston, Arthur ; Blumenthal, Roger S ; Santos, Raul D. ; Feiz, Hamid ; Nasir, Khurram ; Sposito, Andrei. / The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease : The Brazilian study on healthy aging. In: Diabetology and Metabolic Syndrome. 2014 ; pp. 121.
@article{feb9a8785cd24737be2470813b5b16d7,
title = "The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease: The Brazilian study on healthy aging",
abstract = "Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and Methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5{\%} (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.",
keywords = "Aging, Metabolic Syndrome, Obesity, Subclinical CVD",
author = "Lara Roberson and Sameer Shaharyar and Ehimen Aneni and Wladimir Freitas and Michael Blaha and Arthur Agatston and Blumenthal, {Roger S} and Santos, {Raul D.} and Hamid Feiz and Khurram Nasir and Andrei Sposito",
year = "2014",
month = "11",
day = "7",
doi = "10.1186/1758-5996-6-121",
language = "English (US)",
pages = "121",
journal = "Diabetology and Metabolic Syndrome",
issn = "1758-5996",
publisher = "BioMed Central",

}

TY - JOUR

T1 - The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease

T2 - The Brazilian study on healthy aging

AU - Roberson, Lara

AU - Shaharyar, Sameer

AU - Aneni, Ehimen

AU - Freitas, Wladimir

AU - Blaha, Michael

AU - Agatston, Arthur

AU - Blumenthal, Roger S

AU - Santos, Raul D.

AU - Feiz, Hamid

AU - Nasir, Khurram

AU - Sposito, Andrei

PY - 2014/11/7

Y1 - 2014/11/7

N2 - Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and Methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.

AB - Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD. Research design and Methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD. Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS). Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.

KW - Aging

KW - Metabolic Syndrome

KW - Obesity

KW - Subclinical CVD

UR - http://www.scopus.com/inward/record.url?scp=84920837815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920837815&partnerID=8YFLogxK

U2 - 10.1186/1758-5996-6-121

DO - 10.1186/1758-5996-6-121

M3 - Article

SP - 121

JO - Diabetology and Metabolic Syndrome

JF - Diabetology and Metabolic Syndrome

SN - 1758-5996

ER -