The prevalence of low sex steroid hormone concentrations in men in the Third National Health and Nutrition Examination Survey (NHANES III)

Sabine Rohrmann, Elizabeth A Platz, Elizabeth Selvin, Meredith S. Shiels, Corinne E. Joshu, Andy Menke, Manning Feinleib, Shehzad Basaria, Nader Rifai, Adrian S Dobs, Norma F Kanarek, William G Nelson

Research output: Contribution to journalArticle

Abstract

Summary Background Physiologic processes during ageing leading to multi-morbidity and diseases that increase risk of premature death may be influenced by ageing-associated changes in endogenous hormone production. Objective To evaluate the decline in sex steroid hormone levels across age and estimate the number of US men 40+ years old who may have low hormone levels. Design We measured serum testosterone, oestradiol and sex hormone binding globulin by immunoassay in 1351 men 20+ years old in Third National Health and Nutrition Examination Survey. We estimated free hormones by mass action. Results Free testosterone declined most rapidly with age (a 2% decline in geometric mean concentration occurred after ageing 1·3 years), followed by total testosterone (2·4 years), free oestradiol (4·1 years) and total oestradiol (8·1 years). These hormone changes with age translated into 25·0% and 30·2% of men 70+ years old having low total (which we defined as

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalClinical Endocrinology
Volume75
Issue number2
DOIs
StatePublished - Aug 2011

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Nutrition Surveys
Gonadal Steroid Hormones
Hormones
Testosterone
Estradiol
Sex Hormone-Binding Globulin
Premature Mortality
Immunoassay
Morbidity
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

The prevalence of low sex steroid hormone concentrations in men in the Third National Health and Nutrition Examination Survey (NHANES III). / Rohrmann, Sabine; Platz, Elizabeth A; Selvin, Elizabeth; Shiels, Meredith S.; Joshu, Corinne E.; Menke, Andy; Feinleib, Manning; Basaria, Shehzad; Rifai, Nader; Dobs, Adrian S; Kanarek, Norma F; Nelson, William G.

In: Clinical Endocrinology, Vol. 75, No. 2, 08.2011, p. 232-239.

Research output: Contribution to journalArticle

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