TY - JOUR
T1 - The prevalence of hepatitis B virus and hepatitis C virus infection among patients with chronic liver disease in South India
AU - Saravanan, Shanmugam
AU - Velu, Vijayakumar
AU - Kumarasamy, Nagalingeswaran
AU - Shankar, Esaki Muthu
AU - Nandakumar, Subhadra
AU - Murugavel, Kailapuri G.
AU - Balakrishnan, Pachamuthu
AU - Solomon, Sunil Suhas
AU - Solomon, Suniti
AU - Thyagarajan, Sadras Panchatcharam
N1 - Funding Information:
The authors are grateful for the grant-in-aid financial assistance provided by the Indian Council of Medical Research (ICMR), New Delhi. The assistance of gastroenterologists and pathologists of the Government medical colleges is gratefully acknowledged. Thanks are due to the study participants for their active support.
PY - 2008/9
Y1 - 2008/9
N2 - Objective: Determining the identity of hepatitis C virus (HCV) genotypes in liver disease has key implications for ascertaining the duration of antiviral therapy and disease prognosis. We investigated the presence of various genotypes of HCV among 69 chronic liver diseased (CLD) patients with chronic HCV infection. Methods: Sixty-nine consecutive subjects with underlying chronic hepatitis (n = 28), cirrhosis (n = 35), and hepatocellular carcinoma (n = 6), diagnosed by clinical, biochemical, and histological means, were studied. Hepatitis B virus (HBV) and HCV diagnostic markers were used. HCV-RNA was extracted from sera of HCV-infected subjects and subsequently the HCV genotypes were determined using a commercial line probe assay (Inno-LiPA HCV II). Results: Of the 69 CLD cases screened for possible markers of HBV and HCV infection, 39 (57%) were positive for HBV and 30 (43%) were HCV infected. The overall HCV-RNA positivity was 77% (23/30). Of these, the majority were genotype 1b (13/23, 57%), followed by 1a (6/23, 26%), mixed genotypes 3 and 4 (3/23, 13%), and mixed pattern of 1a, 1b, and 4 (1/23, 4.3%). The genotype 1b infected subjects demonstrated significantly elevated transaminase (ALT) levels (p < 0.05) as compared with the other non-1b HCV genotypes. Conclusions: The predominance of HCV genotype 1b among CLD patients could pose a major challenge for the efficient management of HCV disease and the development of effective therapeutic interventions in peninsular India.
AB - Objective: Determining the identity of hepatitis C virus (HCV) genotypes in liver disease has key implications for ascertaining the duration of antiviral therapy and disease prognosis. We investigated the presence of various genotypes of HCV among 69 chronic liver diseased (CLD) patients with chronic HCV infection. Methods: Sixty-nine consecutive subjects with underlying chronic hepatitis (n = 28), cirrhosis (n = 35), and hepatocellular carcinoma (n = 6), diagnosed by clinical, biochemical, and histological means, were studied. Hepatitis B virus (HBV) and HCV diagnostic markers were used. HCV-RNA was extracted from sera of HCV-infected subjects and subsequently the HCV genotypes were determined using a commercial line probe assay (Inno-LiPA HCV II). Results: Of the 69 CLD cases screened for possible markers of HBV and HCV infection, 39 (57%) were positive for HBV and 30 (43%) were HCV infected. The overall HCV-RNA positivity was 77% (23/30). Of these, the majority were genotype 1b (13/23, 57%), followed by 1a (6/23, 26%), mixed genotypes 3 and 4 (3/23, 13%), and mixed pattern of 1a, 1b, and 4 (1/23, 4.3%). The genotype 1b infected subjects demonstrated significantly elevated transaminase (ALT) levels (p < 0.05) as compared with the other non-1b HCV genotypes. Conclusions: The predominance of HCV genotype 1b among CLD patients could pose a major challenge for the efficient management of HCV disease and the development of effective therapeutic interventions in peninsular India.
KW - Chronic liver disease
KW - Genotype 1b
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - India
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U2 - 10.1016/j.ijid.2008.02.006
DO - 10.1016/j.ijid.2008.02.006
M3 - Article
C2 - 18455943
AN - SCOPUS:50349097304
SN - 1201-9712
VL - 12
SP - 513
EP - 518
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
IS - 5
ER -