The Prevalence of Clostridium difficile Infection in Pediatric and Adult Patients with Inflammatory Bowel Disease

Research output: Contribution to journalArticle


Objectives: Adults with inflammatory bowel disease (IBD) have a high prevalence of Clostridium difficile infection (CDI). CDI in children with IBD may differ from adults. We aim to compare the prevalence of CDI in hospitalized pediatric and adult IBD patients and patients without IBD. Methods: The rates of CDI per 1,000 IBD and non-IBD hospitalizations between 1993 and 2012 were examined using the Maryland Health Services Cost Review Commission database. Age, sex and calendar year adjusted incidence rate ratios comparing CDI in pediatrics and adults by type of IBD and with patients without IBD were calculated. p values for trend identifying changes in rates over time were calculated. Results: Among children, the rate of CDI was over 12 times greater in IBD than non-IBD hospitalizations (p 

Original languageEnglish (US)
Pages (from-to)2222-2227
Number of pages6
JournalDigestive Diseases and Sciences
Issue number9
StatePublished - Sep 1 2014



  • Clostridium difficile
  • Inflammatory bowel disease
  • Pediatric

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

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