TY - JOUR
T1 - The prevalence and predictors of active brown adipose tissue in Chinese adults
AU - Zhang, Zhaoyun
AU - Cypess, Aaron M.
AU - Miao, Qing
AU - Ye, Hongying
AU - Liew, Chong Wee
AU - Zhang, Qiongyue
AU - Xue, Ruidan
AU - Zhang, Shuo
AU - Zuo, Chuantao
AU - Xu, Zhensheng
AU - Tang, Qiqun
AU - Hu, Renming
AU - Guan, Yihui
AU - Li, Yiming
PY - 2014
Y1 - 2014
N2 - Objective: Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals. Design: A total of 31 088 consecutive subjects aged ≥ 18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study. Methods: We measured BAT activity via 18F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals. Results: In both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group. Conclusions: In Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.
AB - Objective: Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals. Design: A total of 31 088 consecutive subjects aged ≥ 18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study. Methods: We measured BAT activity via 18F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals. Results: In both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group. Conclusions: In Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.
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U2 - 10.1530/EJE-13-0712
DO - 10.1530/EJE-13-0712
M3 - Article
C2 - 24288355
AN - SCOPUS:84896277618
VL - 170
SP - 359
EP - 366
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 3
ER -