The Pressure of Aging

Majd AlGhatrif, Mingyi Wang, Olga V. Fedorova, Alexei Y. Bagrov, Edward G. Lakatta

Research output: Contribution to journalReview articlepeer-review

Abstract

Significant hemodynamic changes ensue with aging, leading to an ever-growing epidemic of hypertension. Alterations in central arterial properties play a major role in these hemodynamic changes. These alterations are characterized by an initial decline in aortic distensibility and an increase of diastolic blood pressure, followed by a sharp increase in pulse wave velocity (PWV), and an increase in pulse pressure (PP) beyond the sixth decade. However, the trajectories of PWV and PP diverge with advancing age. There is an increased prevalence of salt-sensitive hypertension with advancing age that is, in part, mediated by marinobufagenin, an endogenous sodium pump ligand.

Original languageEnglish (US)
Pages (from-to)81-101
Number of pages21
JournalMedical Clinics of North America
Volume101
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Age-dependent salt-sensitive hypertension
  • Aging
  • Angiotensin II
  • Arterial fibrosis
  • Arterial wall remodeling
  • Hemodynamics
  • Marinobufagenin
  • Pulse wave velocity

ASJC Scopus subject areas

  • Medicine(all)

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