The present state and future direction of integrated gene function analysis

Michael F. Ochs

Research output: Contribution to journalArticle

Abstract

The determination of the function of the protein products of genes has been a major focus of molecular biology since the founding of the discipline. The development of knock-in, knock-down, and transgenic methodologies has greatly speeded laboratory discoveries, while the development of high-throughput measurement technologies for many molecular species has led to the emergence of computational methods capable of predicting functional relationships between genes. In the future, we should see the emergence of quantitative models based on integrated data and laboratory methods that elucidate context-specific functions and identify how gene function depends on changing partners and contexts.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalMethods in molecular biology (Clifton, N.J.)
Volume1101
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Genes
Molecular Biology
Technology
Proteins
Direction compound

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

The present state and future direction of integrated gene function analysis. / Ochs, Michael F.

In: Methods in molecular biology (Clifton, N.J.), Vol. 1101, 2014, p. 3-9.

Research output: Contribution to journalArticle

@article{15832e17ddc4491ea5acaf9777ac05f1,
title = "The present state and future direction of integrated gene function analysis",
abstract = "The determination of the function of the protein products of genes has been a major focus of molecular biology since the founding of the discipline. The development of knock-in, knock-down, and transgenic methodologies has greatly speeded laboratory discoveries, while the development of high-throughput measurement technologies for many molecular species has led to the emergence of computational methods capable of predicting functional relationships between genes. In the future, we should see the emergence of quantitative models based on integrated data and laboratory methods that elucidate context-specific functions and identify how gene function depends on changing partners and contexts.",
author = "Ochs, {Michael F.}",
year = "2014",
doi = "10.1007/978-1-62703-721-1-1",
language = "English (US)",
volume = "1101",
pages = "3--9",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

TY - JOUR

T1 - The present state and future direction of integrated gene function analysis

AU - Ochs, Michael F.

PY - 2014

Y1 - 2014

N2 - The determination of the function of the protein products of genes has been a major focus of molecular biology since the founding of the discipline. The development of knock-in, knock-down, and transgenic methodologies has greatly speeded laboratory discoveries, while the development of high-throughput measurement technologies for many molecular species has led to the emergence of computational methods capable of predicting functional relationships between genes. In the future, we should see the emergence of quantitative models based on integrated data and laboratory methods that elucidate context-specific functions and identify how gene function depends on changing partners and contexts.

AB - The determination of the function of the protein products of genes has been a major focus of molecular biology since the founding of the discipline. The development of knock-in, knock-down, and transgenic methodologies has greatly speeded laboratory discoveries, while the development of high-throughput measurement technologies for many molecular species has led to the emergence of computational methods capable of predicting functional relationships between genes. In the future, we should see the emergence of quantitative models based on integrated data and laboratory methods that elucidate context-specific functions and identify how gene function depends on changing partners and contexts.

UR - http://www.scopus.com/inward/record.url?scp=84891812676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891812676&partnerID=8YFLogxK

U2 - 10.1007/978-1-62703-721-1-1

DO - 10.1007/978-1-62703-721-1-1

M3 - Article

C2 - 24233774

VL - 1101

SP - 3

EP - 9

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -