The studied pediatric patients with chronic lymphocytic thyroiditis or thyrotoxicosis together with their siblings and parents to evaluate the frequency and type of thyroid and other autoantibodies, in order to identify high-risk siblings and to learn more about the inheritance of thyroid autoimmunity. There was a greater incidence of thyroid autoantibodies in siblings and parents of the juveniles with autoimmune thyroid disease compared to controls. Most probands exhibited both microsomal and thyroglobulin antibodies whereas most of their clinically normal siblings showed only thyroglobulin antibody. The presence of both microsomal and thyroglobulin antibodies in siblings of probands imparts a significantly greater risk of subclinical disease than if only thyroglobulin antibody were present. Thyroid autoantibodies were found in about equal frequencies in parents of each sex, indicating that the inheritance can be through either parent. There was an additive relationship between the presence of thyroid autoantibodies in neither, one, or both parents of probands and the number of progeny also with thyroid autoantibodies.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine