The Presence of Frailty in Elderly Persons with Chronic Renal Insufficiency

Michael G. Shlipak, Catherine Stehman-Breen, Linda F. Fried, Xiao Song, David Siscovick, Linda P. Fried, Bruce M. Psaty, Anne B. Newman

Research output: Contribution to journalArticlepeer-review


Background: Frailty has been defined as a tool to define individuals who lack functional reserve and are at risk for functional decline. We hypothesized that chronic renal insufficiency (CRI) would be associated with a greater prevalence of frailty and disability in the elderly. Methods: This cross-sectional analysis used baseline data collected from the Cardiovascular Health Study, which enrolled 5,888 community-dwelling adults aged 65 years or older from 4 clinical centers in the United States. Renal insufficiency is defined as a serum creatinine level of 1.3 mg/dL or greater (≥115 μmol/L) in women and 1.5 mg/dL or greater (≥133 μmol/L) in men. Frailty is defined by the presence of 3 of the following abnormalities: unintentional weight loss, self-reported exhaustion, measured weakness, slow walking speed, and low physical activity. Disability is defined as any self-reported difficulty with activities of daily living. Results: Among 5,808 participants with creatinine levels measured at entry, 15.9% of men (n = 394) and 7.6% of women (n = 254) had CRI. Prevalences of frailty (15% versus 6%; P < 0.001) and disability (12% versus 7%; P = 0.001) were greater in participants with CRI compared with those with normal renal function. After multivariate adjustment for comorbidity, CRI remained significantly associated with frailty (odds ratio, 1.76; 95% confidence interval, 1.28 to 2.41), but not disability (odds ratio, 1.26; 95% confidence interval, 0.94 to 1.69). Conclusion: Elderly persons with CRI have a high prevalence of frailty, which may signal their risk for progression to adverse health outcomes. If confirmed in other studies, identification of frailty in patients with CRI may warrant special interventions to preserve their independence, quality of life, and survival.

Original languageEnglish (US)
Pages (from-to)861-867
Number of pages7
JournalAmerican Journal of Kidney Diseases
Issue number5
StatePublished - May 2004
Externally publishedYes


  • Chronic renal insufficiency (CRI)
  • Disability
  • Elderly
  • Frailty

ASJC Scopus subject areas

  • Nephrology

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