The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body

Machiko Shirahata; Robert S. Fitzgerald

doi:10.1016/0006-8993(91)91301-G

The presence of CO₂/HCO₃^- is essential for hypoxic chemotransduction in the in vivo perfused carotid body

Machiko Shirahata, Robert S. Fitzgerald

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO₂/HCO₃^- (HBA +), but not with hypoxic HBS withouut CO₂/HCO₃^- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO₂/HCO₃^- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.

Original language	English (US)
Pages (from-to)	297-300
Number of pages	4
Journal	Brain research
Volume	545
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91301-G
State	Published - Apr 5 1991
Externally published	Yes

Keywords

CO/O interaction
Carotid chemoreceptor activity
Cat
Hypoxia

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(91)91301-G

Cite this

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title = "The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body",

abstract = "Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA +), but not with hypoxic HBS withouut CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.",

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AU - Shirahata, Machiko

AU - Fitzgerald, Robert S.

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N2 - Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA +), but not with hypoxic HBS withouut CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.

AB - Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA +), but not with hypoxic HBS withouut CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.

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KW - Carotid chemoreceptor activity

KW - Cat

KW - Hypoxia

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