The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body

Machiko Shirahata, Robert S. Fitzgerald

Research output: Contribution to journalArticle


Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA +), but not with hypoxic HBS withouut CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalBrain research
Issue number1-2
StatePublished - Apr 5 1991



  • CO/O interaction
  • Carotid chemoreceptor activity
  • Cat
  • Hypoxia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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