Although Campylobacter pylori has recently been causally linked to active chronic gastritis and peptic ulcer disease, its relationship to nonsteroidal antiinflammatory drug (NSAID) associated gastritis is unclear. We performed a case-control study of 100 patients who had undergone gastric biopsy. Blinded review of Giemsa stained slides demonstrated the presence of C. pylori in 32% of 19 NSAID treated cases with active chronic gastritis vs 3% of 36 controls with chronic gastritis not taking NSAID, and 69% of 45 'positive' controls with active chronic gastritis not taking NSAID (p < 0.001). Our results suggest a possible multifactorial etiology of NSAID associated gastritis.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Rheumatology|
|State||Published - Jan 1 1989|
ASJC Scopus subject areas
- Immunology and Allergy