The prescription pattern of oral nitrates in coronary artery disease: Appropriateness and cost considerations

H. Reuveni, E. E. Aviram, A. Elhayani, M. Lifshitz, R. Peled, Noya Galai, M. Sherf, E. Paran

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the prescription patterns of oral nitrates in terms of appropriateness and cost in a community setting. Methods: A period prevalence, descriptive, applied study. Data including age, gender, type of medication, dosage and cost were extracted from the database of the largest health maintenance organisation (HMO) in Israel. The study population included enrollees over 35 years of age who received oral nitrates at least once during the 12-month study period. Results: Oral nitrates were prescribed for 8007 patients (mean age 72.85 ± 9.59 years, male:female ratio 1:1). A total of 52,694 prescriptions were issued for 56,553 medications, of these 88.1% for mononitrates, which constituted 95% of the annual cost for patients and the HMO. The mean prescribed daily dose for the various drugs ranged from 30% less than to 50% more than the recommended dose. Combination therapy with at least two nitrates, which is not the recommended treatment, was given to 5% of the patients. The recommended alternative treatment will alleviate the financial burden for providers and patients. Conclusions: Improved prescription habits can provide enhanced quality as well as cost savings for patients and providers.

Original languageEnglish (US)
Pages (from-to)595-597
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume57
Issue number8
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Cost of Illness
Nitrates
Prescriptions
Coronary Artery Disease
Health Maintenance Organizations
Costs and Cost Analysis
Cost Savings
Israel
Habits
Therapeutics
Databases
Pharmaceutical Preparations
Population

Keywords

  • Cost
  • Nitrates
  • Prescribing pattern

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The prescription pattern of oral nitrates in coronary artery disease : Appropriateness and cost considerations. / Reuveni, H.; Aviram, E. E.; Elhayani, A.; Lifshitz, M.; Peled, R.; Galai, Noya; Sherf, M.; Paran, E.

In: European Journal of Clinical Pharmacology, Vol. 57, No. 8, 2001, p. 595-597.

Research output: Contribution to journalArticle

Reuveni, H. ; Aviram, E. E. ; Elhayani, A. ; Lifshitz, M. ; Peled, R. ; Galai, Noya ; Sherf, M. ; Paran, E. / The prescription pattern of oral nitrates in coronary artery disease : Appropriateness and cost considerations. In: European Journal of Clinical Pharmacology. 2001 ; Vol. 57, No. 8. pp. 595-597.
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