The precise determination of vascular lumen and stent diameters: Correlation among calibrated angiography, intravascular ultrasound, and pressure-fixed specimens

Jens J. Froelich, Martin Hoppe, Christoph Nahrstedt, Klemens H. Barth, H. Joachim Wagner, Klaus J. Klose

Research output: Contribution to journalArticle

Abstract

Purpose: Luminal diameters measured in vivo by calibrated-catheter angiography and by intravascular ultrasound were correlated with those obtained from pressure-fixed histologic cross-sections to determine the accuracy of both methods. Methods: Angiographic and endosonographic diameter measurements were performed in the center of stents placed in the iliac arteries of 10 miniature pigs and were compared with luminal and stent diameters in postmortem, pressure-fixed, histologic cross-sections from identical locations. Results: Compared with histologic diameters, magnification-corrected angiographic measurements still magnified vascular luminal diameters by 0.7 ± 0.71 mm (r = 0.41, Pearson; p < 0.003, Wilcoxon, matched pairs), whereas intravascular ultrasound measurements proved to be almost identical to the histologic lumina (r = 0.95, Pearson; p > 0.5, Wilcoxon, matched pairs). Similarly, stent diameters correlated well between endosonographic and histologic measurements (r = 0.91; p = 0.002), and less well between angiographic and histologic diameters (r = 0.62; p = 0.002). Conclusion: Since calibrated angiography still overestimates vascular lumina, endosonography is the preferred technique for accurate in vivo measurements.

Original languageEnglish (US)
Pages (from-to)452-456
Number of pages5
JournalCardiovascular and interventional radiology
Volume20
Issue number6
DOIs
StatePublished - Nov 1 1997

Keywords

  • Atherosclerosis
  • Calibrated angiography
  • Catheters
  • Intravascular ultrasound
  • Stents
  • Vessel diameter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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