The power of yeast to model diseases of the powerhouse of the cell

Matthew G. Baile, Steven M. Claypool

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondria participate in a variety of cellular functions. As such, mitochondrial diseases exhibit numerous clinical phenotypes. Because mitochondrial functions are highly conserved between humans and Saccharomyces cerevisiae, yeast are an excellent model to study mitochondrial disease, providing insight into both physiological and pathophysiological processes.

Original languageEnglish (US)
Pages (from-to)241-278
Number of pages38
JournalFrontiers in Bioscience
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Mitochondria
  • Mitochondrial disease
  • Oxidative phosphorylation
  • Review
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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