The potential value of Clostridium difficile vaccine: An economic computer simulation model

Bruce Y. Lee, Michael J. Popovich, Ye Tian, Rachel R. Bailey, Paul J. Ufberg, Ann E. Wiringa, Robert R. Muder

Research output: Contribution to journalArticlepeer-review

Abstract

Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.

Original languageEnglish (US)
Pages (from-to)5245-5253
Number of pages9
JournalVaccine
Volume28
Issue number32
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Clostridium difficile
  • Computer simulation
  • Economics
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'The potential value of Clostridium difficile vaccine: An economic computer simulation model'. Together they form a unique fingerprint.

Cite this