The potential role of mitochondria in pediatric traumatic brain injury

Courtney Robertson, Lucian Soane, Zachary T. Siegel, Gary Fiskum

Research output: Contribution to journalArticle

Abstract

Mitochondria play a central role in cerebral energy metabolism, intracellular calcium homeostasis and reactive oxygen species generation and detoxification. Following traumatic brain injury (TBI), the degree of mitochondrial injury or dysfunction can be an important determinant of cell survival or death. Literature would suggest that brain mitochondria from the developing brain are very different from those from mature animals. Therefore, aspects of developmental differences in the mitochondrial response to TBI can make the immature brain more vulnerable to traumatic injury. This review will focus on four main areas of secondary injury after pediatric TBI, including excitotoxicity, oxidative stress, alterations in energy metabolism and cell death pathways. Specifically, we will describe what is known about developmental differences in mitochondrial function in these areas, in both the normal, physiologic state and the pathologic state after pediatric TBI. The ability to identify and target aspects of mitochondrial dysfunction could lead to novel neuroprotective therapies for infants and children after severe TBI.

Original languageEnglish (US)
Pages (from-to)432-446
Number of pages15
JournalDevelopmental Neuroscience
Volume28
Issue number4-5
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Mitochondria
Pediatrics
Energy Metabolism
Wounds and Injuries
Brain
Cell Death
Reactive Oxygen Species
Cell Survival
Oxidative Stress
Homeostasis
Traumatic Brain Injury
Calcium
Therapeutics

Keywords

  • Apoptosis
  • Energy metabolism
  • Excitotoxicity
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The potential role of mitochondria in pediatric traumatic brain injury. / Robertson, Courtney; Soane, Lucian; Siegel, Zachary T.; Fiskum, Gary.

In: Developmental Neuroscience, Vol. 28, No. 4-5, 08.2006, p. 432-446.

Research output: Contribution to journalArticle

Robertson, Courtney ; Soane, Lucian ; Siegel, Zachary T. ; Fiskum, Gary. / The potential role of mitochondria in pediatric traumatic brain injury. In: Developmental Neuroscience. 2006 ; Vol. 28, No. 4-5. pp. 432-446.
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