The potential role of interleukin-17 in severe asthma

Yui Hsi Wang, Marsha Wills-Karp

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune responses to environmental allergens. Clinical studies suggest that asthma is a heterogeneous disorder with distinct types of inflammatory processes. Accumulating evidence suggests that aberrant interleukin (IL)-17 production is a key determinant of severe forms of asthma. However, the identity of IL-17-producing cells and the factors regulating IL-17 production during the course of allergic inflammation remain elusive. In this review, we summarize the potential IL-17-producing cells and their involvement in the inflammatory responses that mediate distinct features of asthma. The role of proinflammatory cytokines and the complement pathway in regulating the generation of IL-17-producing T cells is also discussed. Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma.

Original languageEnglish (US)
Pages (from-to)388-394
Number of pages7
JournalCurrent allergy and asthma reports
Volume11
Issue number5
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Asthma
  • IL-17
  • Interleukin-17
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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