The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients

Yeohan Song, Julie H Y Tai, Sarah Bartsch, Richard K. Zimmerman, Robert R. Muder, Bruce Lee

Research output: Contribution to journalArticle

Abstract

Staphylococcus aureus infections are a substantial problem for hemodialysis patients. Several vaccine candidates are currently under development, with hemodialysis patients being one possible target population. To determine the potential economic value of an S. aureus vaccine among hemodialysis patients, we developed a Markov decision analytic computer simulation model. When S. aureus colonization prevalence was 1%, the incremental cost-effectiveness ratio (ICER) of vaccination was ≤$25,217/quality-adjusted life year (QALY). Vaccination became more cost-effective as colonization prevalence, vaccine efficacy, or vaccine protection duration increased or vaccine cost decreased. Even at 10% colonization prevalence, a 25% efficacious vaccine costing $100 prevented 29 infections, 21 infection-related hospitalizations, and 9 inpatient deaths per 1000 vaccinated HD patients. Our results suggest that an S. aureus vaccine would be cost-effective (i.e., ICERs ≤ $50,000/QALY) among hemodialysis patients over a wide range of S. aureus prevalence, vaccine costs and efficacies, and vaccine protection durations and delineate potential target parameters for such a vaccine.

Original languageEnglish (US)
Pages (from-to)3675-3682
Number of pages8
JournalVaccine
Volume30
Issue number24
DOIs
Publication statusPublished - May 21 2012
Externally publishedYes

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Keywords

  • Cost-effectiveness
  • Economics
  • Hemodialysis
  • Staphylococcus aureus
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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