The postulated X-inactivation center at Xq27 is most reasonably explained by ascertainment bias: Heterozygous expression of recessive mutations is a powerful means of detecting unbalanced X inactivation [1]

B. R. Migeon, J. T.R. Clarke, P. J. Wilson, C. P. Morris, J. J. Hopwood, R. I. Richards, G. R. Sutherland, P. N. Ray

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