The possible role of hepatitis A virus in the pathogenesis of atherosclerosis

Research output: Contribution to journalArticlepeer-review

Abstract

Latent infection of resting CD4+ T cells represents a major barrier to eradication of human immunodeficiency virus type 1 (HIV-1). The establishment and rate of decay of latent HIV-1 in resting CD+ T cells from 9 acute seroconverters, 7 of whom began to receive highly active antiretroviral therapy (HAART) shortly after presentation, were studied. Before the initiation of therapy, these patients had very high frequencies of latently infected CD4+ T cells, with a median frequency of 205 infectious units per million resting CD4+ T cells. These values are 1 log higher than those seen in chronically infected patients who are not undergoing HAART. The number of latently infected cells declined dramatically after initiation of HAART but then tended to level off at a low but stable level. The biphasic decay of latent HIV in resting CD4+ T cells in acute seroconverters supports current models of pre- and postintegration latency.

Original languageEnglish (US)
Pages (from-to)1583-1587
Number of pages5
JournalJournal of Infectious Diseases
Volume182
Issue number6
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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