The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome

Effrosini P. Economou, Andrew W. Bergen, Andrew C. Warren, Stylianos E. Antonarakis

Research output: Contribution to journalArticle


To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3′ ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.

Original languageEnglish (US)
Pages (from-to)2951-2954
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
Publication statusPublished - Apr 1990



  • β-globin gene cluster
  • Adenosine deaminase gene
  • DNA marker
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Genetics
  • General

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