The poison Dart frog's batrachotoxin modulates Nav1.8

Frank Bosmans, Chantal Maertens, Fons Verdonck, Jan Tytgat

Research output: Contribution to journalArticlepeer-review

Abstract

Batrachotoxin is a potent modulator of voltage-gated sodium channels, leading to irreversible depolarisation of nerves and muscles, fibrillation, arrhythmias and eventually cardiac failure. Since its discovery, field researchers also reported numbness after their skin came into contact with this toxin. Intrigued by this phenomenon, we determined the effect of batrachotoxin on the voltage-gated sodium channel Nav1.8, which is considered to be a key player in nociception. As a result, we discovered that batrachotoxin profoundly modulates this channel: the inactivation process is severely altered, the voltage-dependence of activation is shifted towards more hyperpolarised potentials resulting in the opening of Nav1.8 at more negative membrane potentials and the ion selectivity is modified.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalFEBS Letters
Volume577
Issue number1-2
DOIs
StatePublished - Nov 5 2004

Keywords

  • Batrachotoxin
  • Na1.8
  • Pain
  • Voltage-gated Na channel

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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