The Platelet Lifeline to Cancer: Challenges and Opportunities

Monika Haemmerle, Rebecca Stone, David G. Menter, Vahid Afshar-Kharghan, Anil K. Sood

Research output: Contribution to journalArticle

Abstract

Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment. Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.

Original languageEnglish (US)
JournalCancer Cell
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • anti-platelet therapy
  • aspirin
  • biomarker
  • cancer
  • cancer therapy
  • metastasis
  • microparticles
  • platelets
  • thrombocytosis
  • tumor angiogenesis

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'The Platelet Lifeline to Cancer: Challenges and Opportunities'. Together they form a unique fingerprint.

  • Cite this

    Haemmerle, M., Stone, R., Menter, D. G., Afshar-Kharghan, V., & Sood, A. K. (Accepted/In press). The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.03.002