TY - JOUR
T1 - The Plasmodium bottleneck
T2 - Malaria parasite losses in the mosquito vector
AU - Smith, Ryan C.
AU - Vega-Rodríguez, Joel
AU - Jacobs-Lorena, Marcelo
PY - 2014/8
Y1 - 2014/8
N2 - Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.
AB - Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.
KW - Innate immunity
KW - Malaria
KW - Mosquito
KW - Plasmodium
UR - http://www.scopus.com/inward/record.url?scp=84906772847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906772847&partnerID=8YFLogxK
U2 - 10.1590/0074-0276130597
DO - 10.1590/0074-0276130597
M3 - Article
C2 - 25185005
AN - SCOPUS:84906772847
SN - 0074-0276
VL - 109
SP - 644
EP - 661
JO - Memorias do Instituto Oswaldo Cruz
JF - Memorias do Instituto Oswaldo Cruz
IS - 5
ER -